Main description:

This detailed volume examines the complex study of the assessment of in situ bioavailability and toxicity of organic chemicals in aquatic systems with a toolbox of reliable techniques. Beginning with a section on approaches for chemical analytical and bioanalytical techniques in bioavailability research, the book continues with methods to monitor effects in situ and conduct bioassays to assess the effects of complex environmental samples. It concludes with descriptions of various computational models. Written for the Methods in Pharmacology and Toxicology series, chapters feature the kind of expert implementation advice that leads to greater success in the field.
Authoritative and versatile, In Situ Bioavailability and Toxicity of Organic Chemicals in Aquatic Systems serves as an ideal guide to aid in tackling the challenge of analyzing and understanding chemical pollution in aquatic systems.

Contents:

Part I: Chemical Analytical and Bioanalytical Techniques in Bioavailability Research: Passive Sampling/Dosing and Bioaccumulation Assessments

1. Equilibrium Sampling of Hydrophobic Organic Contaminants in Sediments

Gesine Witt, Julia Bachtin, and Sabine Schafer

2. Passive Sampling of Waterborne Contaminants

Branislav Vrana, Foppe Smedes, and Klara Hilscherova

3. Using Tenax Extractable Concentrations to Determine the Bioavailable Contaminant Fraction in Sediments

Amanda D. Harwood and Samuel A. Nutile

4. Quantifying Bioaccumulation in the Aquatic Environment

Katrine Borga and Anders Ruus

Part II: Monitoring of Effects In Situ and Bioassays to Assess the Effects of Complex Environmental Samples

5. In Situ Determination of Genotoxic Effects in Fish Erythrocytes Using Comet and Micronucleus Assays

Paula Suares Rocha, Bjoern Deutschmann, and Henner Hollert

6. Assessing Adverse Effects of Legacy and Emerging Contaminants in Fish Using Biomarker Analysis and Histopathology in Active Monitoring Scenarios

Amaia Orbea, Eider Bilbao, and Miren P. Cajaraville

7. In Situ Exposure of Aquatic Invertebrates to Detect the Effects of Point and Non-Point Source-Related Chemical Pollution in Aquatic Ecosystems

Mirco Bundschuh and Ralf Schulz

8. Whole Sediment Toxicity Bioassay to Determine Bioavailability and Effects of Aquatic Contaminants Using Zebrafish Embryos

Sabrina Schiwy, Mirna Velki, and Henner Hollert

9. Nematode-Based Effect Assessment in Freshwater Sediments

Arne Haegerbaeumer, Sebastian Hoess, and Walter Traunspurger

Part III: Computational Models for Interspecies Comparison and Extrapolation from the Lab to the Field

10. In Vitro-In Vivo Extrapolation to Predict Bioaccumulation and Toxicity of Chemicals in Fish Using Physiologically-Based Toxicokinetic Models

Julita Stadnicka-Michalak and Kristin Schirmer

11. Cross-Species Extrapolation Using a Simplifed In Vitro Tissue Explant Assay in Fish

Bryanna Eisner, Jon Doering, Shawn Beitel, and Markus Hecker

12. Extrapolation of Laboratory-Measured Effects to Fish Populations in the Field

Charles R.E. Hazlerigg