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Immune Effects of Biopharmaceuticals and Nanomedicines
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Main description:

The enormous advances in the immunology of biotherapeutics and nanomedicines in the past two decades have necessitated an authoritative and comprehensive reference that can be relied upon by immunologists, biomedical researchers, physicians, pharmaceutical and formulation scientists, clinicians, regulatory personnel, technology transfer officers, venture capitalists, and policy makers alike. This book provides a broad survey of various interconnected topics, all accomplished in a user-friendly format. The chapters are devoted to the immune stimulatory and suppressive effects of antibodies, peptides and other biopharmaceuticals, drug carrier liposomes, micelles, polymers, polymeric vesicles, dendrimers, carbon nanotubes, and other nanomedicines (with and without surface targeting ligands). The text discusses the state of the art in nanoparticle-formulated therapeutic and preventive vaccines along with their potential molecular mechanisms underlying immunogenicity. The latter phenomenon is addressed as an adverse effect of monoclonal antibody-based biopharmaceuticals and nanomedicines. Yet another adverse immune effect of monoclonals and nanomedicines, complement activation-related pseudoallergy (CARPA), is discussed in unprecedented detail in terms of occurrence, prediction, prevention, and mechanism. The range of the contributing authors accurately reflects the diverse and rapidly evolving fields of biotherapeutics, nanomedicines, nanoimmunology, and nanotoxicology. The book's multidisciplinary and in-depth approach makes it a standard reference in this expansive and interdisciplinary field.


Proteins as Medicines: The Era of Biologics
Raj Bawa, Janos Szebeni, Thomas J. Webster, and Gerald F. Audette

Immunological Issues with Medicines of Nano Size: The Price of Dimension Paradox
Janos Szebeni and Raj Bawa

Immunotherapy and Vaccines
Johanna Poecheim and Gerrit Borchard

Emerging Trends in Delivery of Novel Vaccine Formulations
Trinh Phuong Vo, Rikhav P. Gala, Thripthy Chandran, Sucheta D'Sa, and Ruhi V. Ubale

Current Understanding of Interactions between Nanoparticles and the Immune System
Marina A. Dobrovolskaia, Michael Shurin, and Anna A. Shvedova

Auto-antibodies as Biomarkers for Disease Diagnosis
Angelika Lueking, Heike Gohler, and Peter Schulz-Knappe

The Accelerated Blood Clearance Phenomenon of PEGylated Nanocarriers
Amr S. Abu Lila and Tatsuhiro Ishida

Anti-PEG Immunity Against PEGylated Therapeutics
Amr S. Abu Lila and Tatsuhiro Ishida
Complement Activation: Challenges to Nanomedicine Development
Dennis E. Hourcade, Christine T. N. Pham, and Gregory M. Lanza

Intravenous Immunoglobulin at the Borderline of Nanomedicines and Biologicals: Antithrombogenic Effect via Complement Attenuation
Milan Basta

Lessons Learned from the Porcine CARPA Model: Constant and Variable Responses to Different Nanomedicines and Administration Protocols
Rudolf Urbanics, Peter Bedocs, and Janos Szebeni

Blood Cell Changes in Complement Activation-Related Pseudoallergy: Intertwining of Cellular and Humoral Interactions
Zsofia Patko and Janos Szebeni

Immune Reactions in the Delivery of RNA Interference-Based Therapeutics: Mechanisms and Opportunities
Kaushik Thanki, Emily Falkenberg, Monique Gangloff, and Camilla Foged

Lipid Nanoparticles Technology Induced Immunomodulatory Effects of siRNA
Ranjita Shegokar and Prabhat Mishra

Nanovaccines against Intracellular Pathogens Using Coxiella burnetii as a Model Organism
Erin J. van Schaik, Anthony E. Gregory, Gerald F. Audette, and James E. Samuel

Immunogenicity Assessment for Therapeutic Protein Products

Assay Development and Validation for Immunogenicity Testing of Therapeutic Protein Products: Guidance for Industry

The "Sentinel": A Nanomedical Strategy for Radical Immune System Enhancement
Frank Boehm and Angelika Domschke

Immunotherapy for Gliomas and Other Intracranial Malignancies
Mario Ganau, Gianfranco K. I. Ligarotti, Salvatore Chibbaro, and Andrea Soddu

Liposome-Induced Complement Activation-Related Pseudoallergy
Amr S. Abu Lila, Janos Szebeni, and Tatsuhiro Ishida


ISBN-13: 9789814774529
Publisher: Pan Stanford Publishing Pte Ltd
Publication date: October, 2017
Pages: 950
Weight: 571g
Availability: Contact supplier
Subcategories: Biomedical Engineering, Immunology


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