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Handbook of Cancer Vaccines
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Main description:

An authoritative survey of the scientific background for therapeutic cancer vaccines, the challenges to their development, and their current uses in treating cancer. The authors examine the basic issues that effect all vaccines (such as immune adjuvants and prime-boost strategies), describe the methods for antigen discovery, and review the preclinical development phases for each major vaccine strategy. They also spell out the clinical results for cancer vaccines now beginning to be used in the treatment of many common cancers.


Back cover:

The quest to harness the immune system for the treatment of cancer has been of great interest for more than 100 years, but new discoveries illuminating the requirements for immune activation and recognition of cancers have greatly increased the promise of reaching this goal. In Handbook of Cancer Vaccines, leading scientific investigators and clinicians distill the vast body of literature on cancer vaccines to create an authoritative survey of the scientific background for such therapeutic vaccines, the challenges to their development, and their current uses in treating cancer. The authors examine the basic issues that affect all vaccines (such as immune adjuvants and prime-boost strategies), describe cutting-edge methods for antigen discovery, and review the preclinical development phases for each major vaccine strategy. Topics of particular interest include the clinical results for cancer vaccines now beginning to be used in the treatment of many common cancers, the monitoring of biologic responses to these vaccines, and the statistical and regulatory issues affecting the design and conduct of their clinical trials.

Comprehensive and authoritative, the Handbook of Cancer Vaccines makes available to medical oncologists and immunologists a cutting-edge synthesis of the scientific rationale, preclinical data, and clinical results for the powerful new generation of vaccines now under development for the treatment of a wide range of human cancers.


Contents:

Part I: Basic Science of Tumor Antigens and Immune Activation

Biology of the Cancer Vaccine Immune Response
Michael A. Morse, Timothy M. Clay, and H. Kim Lyerly

The Rational Design of T-Cell Epitopes With Enhanced Immunogenicity
John Fikes

Identification of Tumor Antigens Using Subtraction and Microarrays
Jiangchun Xu

Tumor Antigen Discovery With T Cells
Paul F. Robbins

Targeting Viral Antigens for the Treatment of Malignancies
Gretchen L. Eiben, Diane M. Da Silva, Steven C. Fausch, Amanda M. Krier, I. Caroline Le Poole, Megan E. Papineau, Michael I. Nishimura, and W. Martin Kast

Immune Defects in Cancer
Dmitry Gabrilovich and Vladimir Pisarev

Escape of Tumors From the Immune System: Role of the Transforming Growth Factor-b-Signaling Pathway
Gerard C. Blobe

Part II: General Vaccine and Immunotherapy Strategies

Immune Adjuvants
Jory R. Baldridge, Susan Hand Zimmermann, and Sally P. Mossman

Heterologous Prime-Boost Vaccination in Tumor Immunotherapy
Michael J. Palmowski and Caroline Smith

Peptide-Based Vaccines
Carmen M. Berger, Keith L. Knutson, Lupe G. Salazar, Kathy Schiffman, and Mary L. Disis

Antibody-Inducing Cancer Vaccines Against Cell-Surface Carbohydrate Antigens
Govind Ragupathi, John Gathuru, and Philip O. Livingston

Anti-Idiotype Vaccines
Sunil K. Chatterjee, Malaya Bhattacharya-Chatterjee, and Kenneth A. Foon

Pox Viral Vaccines
James L. Gulley, Philip M. Arlen, and Jeffrey Schlom

Utility of Adenovirus-Based Vectors for Multiple Cancer Vaccine Approaches
Zachary Hartman and Andrea Amalfitano

Alphaviral-Based Strategies for the Immunotherapy of Cancer
Edward L. Nelson and Jonathan Smith

DNA Vaccines
Michael Bereta and Howard L. Kaufman

Whole-Cell Vaccines
Timothy M. Clay, Paul J. Mosca, H. Kim Lyerly, and Michael A. Morse

Gene-Modified Tumor-Cell Vaccines
Leisha A. Emens and Elizabeth M. Jaffee

Hapten-Modified Tumor Vaccines
David Berd

Chaperone Proteins/Heat Shock Proteins As Anticancer Vaccines
Michael W. Graner and Emmanuel Katsanis

Dendritic Cell Vaccines
Madhav V. Dhodapkar

Exosomes for Immunotherapy of Cancer
Nathalie Chaput, N. E. C. Schartz, Fabrice Andre, and Laurence Zitvogel

Immunocytokines for Cancer Immunotherapy
Paul M. Sondel and Steven D. Gillies

T-Cell Adoptive Immunotherapy
Gregory E. Plautz, Peter A. Cohen, David E. Weng, and Suyu Shu

Part III: Tumor-Specific Vaccine Development

Melanoma Vaccines
Jeffrey Weber

Allogenic Melanoma Lysate Vaccines
Malcolm S. Mitchell

Renal Cancer Vaccines
Hyung L. Kim, Barbara J. Gitlitz, and Robert A. Figlin

Vaccines for Hematological Malignancies
Qing Yi

Vaccines for the Immunotherapy of Prostate Cancer
Boris Minev and Michael L. Salgaller

Vaccine Therapy for Breast and Ovarian Cancers
Susan E. Smith and Alison T. Stopeck

Vaccine Therapy for Gastrointestinal Cancers
John L. Marshall

Vaccines for Lung Cancer
Michael A. Morse, Jennifer Garst, and Eric Toloza

Vaccines for Other Tumors
Michael A. Morse

Part IV: Clinical Trials and Immune Analyses

Clinical Trial Designs for Therapeutic Vaccine Studies
Richard Simon

Analysis of Cellular Immune Responses in Cancer Vaccine Trials
Timothy M. Clay, Michael A. Morse, Paul J. Mosca, Amy Hobeika, Donna Niedzwiecki, and H. Kim Lyerly

Analysis of Humoral Immune Responses in Vaccine Trials
Rajasekharan Somasundaram, Tianqian Zhang, and Dorothee Herlyn

Regulatory Issues Affecting Tumor Vaccines
Mark O. Thornton, Alexand


PRODUCT DETAILS

ISBN-13: 9781468498189
Publisher: Springer (Humana Press)
Publication date: July, 2012
Pages: 592
Weight: 1149g
Availability: POD
Subcategories: Oncology
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CUSTOMER REVIEWS

Average Rating 

"This is an excellent resource for anyone interested in tumor immunotherapy. It is truly a comprehensive review of vaccination strategies for the treatment of cancer. The third section looks at the results of vaccine-based clinical trials for various malignancies. This section is an exceptional reference for oncologists. The chapters on melanoma are particularly helpful in sorting through the saga of vaccination for this deadly disease. The concluding section, important for clinical researchers, focuses on clinical trial design, the analysis of immune responses, and vaccine regulatory issues. " -Doody's Health Sciences Book Review Journal

"Highly recommended for medical schools and hospital libraries." - E-STREAMS

"...Comprehensive and authoritative...makes available to medical oncologists and immunologists a cutting-edge synthesis of the scientific rationale, preclinical data, and clinical results for the powerful new generation of vaccines now under development and treatment of a wide range of human cancers." - Tumori