(To see other currencies, click on price)
MORE ABOUT THIS BOOK
Main description:
An authoritative survey of the scientific background for therapeutic cancer vaccines, the challenges to their development, and their current uses in treating cancer. The authors examine the basic issues that effect all vaccines (such as immune adjuvants and prime-boost strategies), describe the methods for antigen discovery, and review the preclinical development phases for each major vaccine strategy. They also spell out the clinical results for cancer vaccines now beginning to be used in the treatment of many common cancers.
Contents:
Part I: Basic Science of Tumor Antigens and Immune Activation
Biology of the Cancer Vaccine Immune Response
Michael A. Morse, Timothy M. Clay, and H. Kim Lyerly
The Rational Design of T-Cell Epitopes With Enhanced Immunogenicity
John Fikes
Identification of Tumor Antigens Using Subtraction and Microarrays
Jiangchun Xu
Tumor Antigen Discovery With T Cells
Paul F. Robbins
Targeting Viral Antigens for the Treatment of Malignancies
Gretchen L. Eiben, Diane M. Da Silva, Steven C. Fausch, Amanda M. Krier, I. Caroline Le Poole, Megan E. Papineau, Michael I. Nishimura, and W. Martin Kast
Immune Defects in Cancer
Dmitry Gabrilovich and Vladimir Pisarev
Escape of Tumors From the Immune System: Role of the Transforming Growth Factor-b-Signaling Pathway
Gerard C. Blobe
Part II: General Vaccine and Immunotherapy Strategies
Immune Adjuvants
Jory R. Baldridge, Susan Hand Zimmermann, and Sally P. Mossman
Heterologous Prime-Boost Vaccination in Tumor Immunotherapy
Michael J. Palmowski and Caroline Smith
Peptide-Based Vaccines
Carmen M. Berger, Keith L. Knutson, Lupe G. Salazar, Kathy Schiffman, and Mary L. Disis
Antibody-Inducing Cancer Vaccines Against Cell-Surface Carbohydrate Antigens
Govind Ragupathi, John Gathuru, and Philip O. Livingston
Anti-Idiotype Vaccines
Sunil K. Chatterjee, Malaya Bhattacharya-Chatterjee, and Kenneth A. Foon
Pox Viral Vaccines
James L. Gulley, Philip M. Arlen, and Jeffrey Schlom
Utility of Adenovirus-Based Vectors for Multiple Cancer Vaccine Approaches
Zachary Hartman and Andrea Amalfitano
Alphaviral-Based Strategies for the Immunotherapy of Cancer
Edward L. Nelson and Jonathan Smith
DNA Vaccines
Michael Bereta and Howard L. Kaufman
Whole-Cell Vaccines
Timothy M. Clay, Paul J. Mosca, H. Kim Lyerly, and Michael A. Morse
Gene-Modified Tumor-Cell Vaccines
Leisha A. Emens and Elizabeth M. Jaffee
Hapten-Modified Tumor Vaccines
David Berd
Chaperone Proteins/Heat Shock Proteins As Anticancer Vaccines
Michael W. Graner and Emmanuel Katsanis
Dendritic Cell Vaccines
Madhav V. Dhodapkar
Exosomes for Immunotherapy of Cancer
Nathalie Chaput, N. E. C. Schartz, Fabrice Andre, and Laurence Zitvogel
Immunocytokines for Cancer Immunotherapy
Paul M. Sondel and Steven D. Gillies
T-Cell Adoptive Immunotherapy
Gregory E. Plautz, Peter A. Cohen, David E. Weng, and Suyu Shu
Part III: Tumor-Specific Vaccine Development
Melanoma Vaccines
Jeffrey Weber
Allogenic Melanoma Lysate Vaccines
Malcolm S. Mitchell
Renal Cancer Vaccines
Hyung L. Kim, Barbara J. Gitlitz, and Robert A. Figlin
Vaccines for Hematological Malignancies
Qing Yi
Vaccines for the Immunotherapy of Prostate Cancer
Boris Minev and Michael L. Salgaller
Vaccine Therapy for Breast and Ovarian Cancers
Susan E. Smith and Alison T. Stopeck
Vaccine Therapy for Gastrointestinal Cancers
John L. Marshall
Vaccines for Lung Cancer
Michael A. Morse, Jennifer Garst, and Eric Toloza
Vaccines for Other Tumors
Michael A. Morse
Part IV: Clinical Trials and Immune Analyses
Clinical Trial Designs for Therapeutic Vaccine Studies
Richard Simon
Analysis of Cellular Immune Responses in Cancer Vaccine Trials
Timothy M. Clay, Michael A. Morse, Paul J. Mosca, Amy Hobeika, Donna Niedzwiecki, and H. Kim Lyerly
Analysis of Humoral Immune Responses in Vaccine Trials
Rajasekharan Somasundaram, Tianqian Zhang, and Dorothee Herlyn
Regulatory Issues Affecting Tumor Vaccines
Mark O. Thornton, Alexand
PRODUCT DETAILS
Publisher: Springer (Humana Press Inc.)
Publication date: July, 2012
Pages: 592
Weight: 1149g
Availability: Available
Subcategories: Oncology
From the same series
