This collection explores up-to-date descriptions of known G protein-coupled receptor kinase (GRK)-dependent mechanisms, both associated with G protein-coupled receptor (GPCR) functions and the receptor-independent. The chapters cover a wide range of studies from invertebrates to humans, with sections of the volume covering GRK structure, mechanisms of activation, and interaction with GPCRs, GRKs in cell signaling, as well as physiological and pathophysiological mechanisms regulated by GRKs. Written for the Methods in Pharmacology and Toxicology series, this book features the kind of practical detail necessary for success in the laboratory. Authoritative and timely, G Protein-Coupled Receptor Kinases features the kind of comprehensive mechanistic elucidation of GRK functions and their regulation in cells necessary for a better understanding of cell biology as well as for devising novel research approaches and therapeutic strategies.
Part I: Introduction 1. G Protein-Coupled Receptor Kinases (GRKs) History: Evolution and Discovery Vsevolod V. Gurevich and Eugenia V. Gurevich Part II: GRK Structure, Mechanisms of Activation, and Interaction with GPCRs 2. Structure and Function of G Protein-Coupled Receptor Kinases 1 and 7 Tivadar Orban and Krzysztof Palczewski 3. Visual G Protein-Coupled Receptor Kinases Chih-Chun Hsu and Ching-Kang Jason Chen 4. Molecular Basis for Targeting, Inhibition, and Receptor Phosphorylation in the G Protein-Coupled Receptor Kinase 4 Subfamily Tyler S. Beyett, Sumit J. Bandekar, and John J.G. Tesmer 5. "Barcode" and Differential Effects of GPCR Phosphorylation by Different GRKs Kunhong Xiao and Hongda Liu Part III: GRKs in Cell Signaling 6. Cell-Type Specific GRK2 Interactomes: Physiopathological Implications Federico Mayor, Jr., Rocio Vila-Bedmar, Laura Nogues, Marta Cruces-Sande, Elisa Lucas, Veronica Rivas, Clara Reglero, Petronila Penela, and Cristina Murga 7. Differential Regulation of IGF-1 and Insulin Signaling by GRKs Leonard Girnita, Ada Girnita, and Caitrin Crudden 8. Differential Control of Potassium Channel Activity by GRK2 Adi Raveh, Liora Guy-David, and Eitan Reuveny Part IV: Physiological and Pathophysiological Mechanisms Regulated by GRKs 9. Critical Role of GRK2 in the Prevention of Chronic Pain Faiza Baameur, Pooja Singhmar, Cobi J. Heijnen, and Annemieke Kavelaars 10. Roles of GRK Dysfunction in Alzheimer's Pathogenesis William Z. Suo 11. Regulation of Dopamine-Dependent Behaviors by G Protein-Coupled Receptor Kinases Eugenia V. Gurevich, Raul R. Gainetdinov, and Vsevolod V. Gurevich 12. G Protein-Coupled Receptors and Their Kinases in Cardiac Regulation Alessandro Cannavo, Claudio de Lucia, and Walter J. Koch 13. GRK Roles in C. elegans Jordan F. Wood and Denise M. Ferkey 14. Evolutionarily Conserved Role of G Protein-Coupled Receptor Kinases in the Hedgehog Signaling Pathway Dominic Maier and David R. Hipfner