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Therapeutic Uses of Botulinum Toxin
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Main description:

Justinius Kerner, a German medical officer and poet, was the first to realize that botulinum toxin potentially might be useful for therapeutic purposes. Kerner made this observation in 1822, but he did not call the toxin “botulinum toxin. ” Instead, Kerner called it the substance in “wirkenden stoffes,” which translates to “bad sausages. ” Kerner realized that there was a “fat poison” or “fatty acid” within sausages that produced the toxic effects that we now know as botulism. Nearly a century would pass before the bacterium producing the toxin would be isolated and the toxin ultimately renamed “botulinum toxin. ” As farsighted as Kerner was, it is doubtful that even he could have predicted just how much potential therapeutic punch was packed within his wirkenden stoffes. It was not until 1978, more than a century and a half after Kerner’s prediction, that Dr. Allan Scott received Food and Drug Administration approval to test botulinum toxin type A in human volunteers. We do not yet have a comprehensive understanding of precisely how botulinum toxin works in the human body or how our bodies fully respond to the toxin. We do know that it temporarily paralyzes muscle by inhibiting the release of acetylcholine, and it also appears to inhibit the release of other neurotransmitters.


Defines our current understanding of botulinum toxin and its method of action

Presents therapeutic uses across a variety of medical subspecialties and patient populations

Encourages responsible research into new and novel uses of botulinum toxin

Back cover:

Therapeutic Uses of Botulinum Toxin outlines and examines our current understanding of botulinum toxin and its various therapeutic applications. The editors explore how this novel compound fits into a wide variety of treatment algorithms across medical subspecialties. Each chapter focuses on a particular symptom and explains how botulinum toxin is currently used for treatment. The chapter authors are all leaders in their fields and are respected for their progressive approach to treatment. Physicians will benefit not only from those chapters devoted to their particular sub-specialty, but from the inspiring success resulting from the use of botulinum toxin in other patient populations. The concluding chapter examines questions of immunity, explores economic issues, and attempts to forecast future directions for this novel and somewhat mysterious drug. Clinicians across a wide variety of disciplines will refer to this comprehensive reference time and time again.



Chapter 1: History and Mechanism of Action
Zinovy Meyler, DO, Grant Cooper, MD

Chapter 2: Spasticity
Elise Weiss, MD, David Lin, MD

Chapter 3: Radiation Fibrosis Syndrome Applications - Trismus, Trigeminal Neuralagia, and Cervical Dystonia
Michael Stubblefield, MD

Chapter 4: Back Pain
Rebecca Brown, MD*, Avniel Klein MD*, Alex Visco, MD, Joseph E. Herrera, DO
*These authors contributed equally and are co-first authors. Note to Humana -- If this is ever done, do this. Otherwise, just make Rebecca the first author. Thanks.

Chapter 5: Piriformis Syndrome
Loren M. Fishman, MD, Alena Polesin, MD, Steven Sampson, DO

Chapter 6: Plantar Fasciitis
Mary S. Babcock DO
Chapter 7: Headache
Jerome S. Schwartz, MD, Phillip Song, MD, Andrew Blitzer, MD, DDS
Chapter 8: Spasmodic Dysphonia
Jerome S. Schwartz, MD, Phillip Song, MD, Andrew Blitzer, MD, DDS
Chapter 9: Sialorrhea and Frey's Syndrome.
Phillip C. Song, MD, Jerome Schwartz, MD, and Andrew Blitzer, MD. DDS.

Chapter 10: Cosmetic Applications
Tara D. Miller, MD, Isaac M. Neuhaus, MD
Chapter 11: Hyperhidrosis
Joely Kaufman, MD, FAAD, Leslie Baumann, MD, FAAD

Chapter 12: Urologic Applications
David E. Rapp, MD, Gregory T. Bales, MD
Chapter 13: Gastrointestinal Applications: Achalasia, Gastroparesis, and Anal Fissure

Shayan Irani, MD, Frank Friedenberg, MD
Chapter 14: Blepharospasm
Amir Cohen, MD, MBA, Marc J. Spirn, MD, David Khoramian, BA,
and C. Robert Bernardino MD
Chapter 15: Economics, Immunity, and Future Directions
Victoria Chan Harrison, MD, David Lin, MD


ISBN-13: 9781597452472
Publisher: Springer (Humana Press)
Publication date: June, 2007
Pages: 254

Subcategories: Dermatology, Pharmacology