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Testicular Autoimmunity
Immunoandrology of male infertility
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Main description:

It has long been suspected that testicular autoimmunity could be one of the causes of idiopathic male infertility. However, it is very difficult to estimate the incidence of testicular autoimmunity in men, as most male patients first realize they are infertile when they start trying to conceive a child, and there is a possibility that their testes may already exhibit the end stage of testicular autoimmunity, in which lymphocytic inflammation and immunoglobulin deposition in their testes subsided long ago and only the spermatogenic disorder remains. Therefore, autopsy or biopsy for testicular tissues in men before the end stage of testicular autoimmunity and investigations using testicular autoimmunity model animals are needed to determine the epidemiology of testicular autoimmunity.
In this book, the author discusses “the immunological fragility of testis,” reviewing the autopsy data in men and presenting experimental data using murine models of autoimmune orchitis that has been induced by immunizing with viable syngeneic testicular germ cells alone. Testicular autoimmunity in animals is also discussed. In summary, the book provides useful information not only to researchers who are interested in immunologic male infertility, but to clinical professionals who treat these patients at hospitals.


From biological background to recent research data on testicular autoimmunity

Covers not only the autopsy and biopsy data for humans, but also experimental data using model animals

Describes new murine models of autoimmune orchitis


​Biological background of testicular autoimmunity (evolution and development of immune system and gonadal system, gamate immunology). - Testicular autoimmunity in men (epidemiology, etiology, pathology, pathogenesis, treatment). - Testicular autoimmunity in mice (pathology, pathogenesis and treatment of various murine models). - Testicular autoimmunity in other animals (pathology, pathogenesis and treatment in guinea pigs, rats, mink, dogs and boars). -  Summary and future directions of testicular autoimmunity.


ISBN-13: 9784431544609
Publisher: Springer (Springer Japan)
Publication date: July, 2017
Pages: 300

Subcategories: Reproductive Medicine, Urology


Dr. Masahiro Itoh obtained PfD degree in Division of Medicine, Kagawa University, in 1987. he started his carrier as an assistant professor at Kagawa University, and promoted to full Professor in 2001, at Tokyo Medical University. He is one of the top scientists in Japan and well-known as he succeeded in making new murine models of autoimmune orchitis.