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Specific Gene Expression and Epigenetics
The Interplay Between the Genome and Its Environment
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Main description:

This title includes a number of Open Access chapters. This new volume on gene expression and epigenetics discusses environmental effects related to specific gene expression. The book also shows methods for bioinformatic analysis of the epigenome. The book is broken into two sections: the first looks at eukaryotic DNA methylation and the second addresses how to integrate genomic medicine into clinical practice. The book includes chapters on these topics: * Gene expression in colon cancer tissue * Epigenetics in human acute kidney injury * Embryologically relevant candidate genes in MRKH patients * DNA methylation in common skeletal disorders * Causal relationships in genomics * Predicting severe asthma exacerbations in children * Epigenetic understanding of gene-environment interactions in psychiatric disorders


Introduction Part I: Eukaryotic DNA Methylation Renal Kallikrein Excretion and Epigenetics in Human Acute Kidney Injury: Expression, Mechanisms and Consequences; Sun Woo Kang, Pei-an Betty Shih, Roy O. Mathew, Manjula Mahata, Nilima Biswas, Fangwen Rao, Liying Yan, Josee Bouchard, Rakesh Malhotra, Ashita Tolwani, Srikrishna Khandrika, Ravindra L. Mehta, and Daniel T. O'Connor COX-2 Gene Expression in Colon Cancer Tissue Related to Regulating Factors and Promoter Methylation Status; Annika Gustafsson Asting, Helena Caren, Marianne Andersson, Christina Lonnroth, Kristina Lagerstedt, and Kent Lundholm Down-Regulation of Promoter Methylation Level of CD4 Gene After MDV Infection in MD-Susceptible Chicken Line; Juan Luo, Ying Yu, Huanmin Zhang, Fei Tian, Shuang Chang, Hans H. Cheng, and Jiuzhou Song A Combination of Transcriptome and Methylation Analyses Reveals Embryologically Relevant Candidate Genes in MRKH Patients; Katharina Rall, Gianmaria Barresi, Michael Walter, Sven Poths, Karina Haebig, Karin Schaeferhoff, Birgitt Schoenfisch, Olaf Riess, Diethelm Wallwiener, Michael Bonin, and Sara Brucker The Role of DNA Methylation in Common Skeletal Disorders; Jesus Delgado-Calle and Jose A. Riancho Enrichment-Based DNA Methylation Analysis Using Next-Generation Sequencing: Sample Exclusion, Estimating Changes in Global Methylation, and the Contribution of Replicate Lanes; Michael P. Trimarchi, Mark Murphy, David Frankhouser, Benjamin A. T. Rodriguez, John Curfman, Guido Marcucci, Pearlly Yan, and Ralf Bundschuh Part II: Integrating Genomic Medicine into the Clinical Practice Assessing Causal Relationships in Genomics: From Bradford-Hill Criteria to Complex Gene-Environment Interactions and Directed Acyclic Graphs; Sara Geneletti, Valentina Gallo, Miquel Porta, Muin J. Khoury, and Paolo Vineis Genome Wide Association Study to Predict Severe Asthma Exacerbations in Children Using Random Forests Classifiers; Mousheng Xu, Kelan G. Tantisira, Ann Wu, Augusto A. Litonjua, Jen-hwa Chu, Blanca E. Himes, Amy Damask, and Scott T. Weiss Potential Utility of Natural Products as Regulators of Breast Cancer-Associated Aromatase Promoters; Shabana I. Khan, Jianping Zhao, Ikhlas A. Khan, Larry A. Walker, and Asok K. Dasmahapatra Therapeutic Potential of Cladribine in Combination with STAT3 Inhibitor Against Multiple Myeloma; Jian Ma, Shuiliang Wang, Ming Zhao, Xin-Sheng Deng, Choon-Kee Lee, Xiao-Dan Yu, and Bolin Liu Epigenetic Understanding of Gene-Environment Interactions in Psychiatric Disorders: A New Concept of Clinical Genetics; Takeo Kubota, Kunio Miyake, and Takae Hirasawa An Imprinted Rheumatoid Arthritis Methylome Signature Reflects Pathogenic Phenotype; John W. Whitaker, Robert Shoemaker, David L. Boyle, Josh Hillman, David Anderson, Wei Wang, and Gary S. Firestein Index


ISBN-13: 9781482253856
Publisher: Elsevier (Apple Academic Press Inc.)
Publication date: March, 2014
Pages: 328

Subcategories: Genetics