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RNA Processing
Disease and Genome-Wide Probing
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Main description:

Ribonucleic acid (RNA) binding proteins currently number in the thousands and defects in their function are at the heart of diseases such as cancer and neurodegeneration. RNA binding proteins have become implicated in the intricate control of surprisingly diverse biological settings, such as circadian rhythm, stem cell self-renewal, oncogenesis and germ cell development. This book surveys a range of genome-wide and systems approaches to studying RNA binding proteins, the importance of RNA binding proteins in development, cancer and circadian rhythm.


Contents:

Experimental and computational considerations in the study of RNA binding protein-RNA interactions.- Genome-wide approaches for RNA structure probing.- Tethered function assays as tools to elucidate the molecular roles of RNA binding proteins.- Single molecule approaches in RNA-protein interactions.- RNA dynamics in the control of circadian rhythm.- Roles of RNA binding proteins and post-transcriptional regulation in driving male germ cell development in the mouse.- Regulation of stem cell self-renewal and oncogenesis by RNA binding proteins.- Controlling the editor: the many roles of RNA binding proteins in regulating A-to-I RNA editing.- Mutations in splicing factors and cancer.- Regulation of tissue-specific alternative splicing: C. elegans as a model system.- RNA Granules and Diseases-A Case Study of Stress Granules in ALS and FTLD.- Post-translational modifications and RNA-binding proteins.


PRODUCT DETAILS

ISBN-13: 9783319290737
Publisher: Springer (Springer International Publishing AG)
Publication date: May, 2016
Pages: None

Subcategories: Anatomy, Genetics