Among the many GPCRs discovered, the calcitonin family of receptors comprise of members that regulate a number of physiological processes and are involved in many pathological conditions. Therefore, understanding how these receptors function is a critical question in the field. When Foord and his colleagues discovered that a single transmembrane protein called Receptor Activity Modifying Proteins (RAMPs) could modulate the surface expression of GPCRs of the calcitonin family, it widely opened the field of receptor life cycle. Hundreds of studies have confirmed the importance of RAMPs in the life cycle of this receptor family. Receptor biology is a rapidly expanding field and with the advances in cell and molecular biology and in vivo techniques, it is very likely that the field of RAMPs will explode further and many unanswered questions will be answered with in the next few years.
Source of basic studies that range from biochemistry to molecular biology to receptor pharmacology and physiology
Written by authors well known in the RAMPs field
Provides information for scientists at different stages of their career including graduate students, post-doctoral fellows and senior scientists who are new to the RAMPs field
Introduction to RAMPs.- RAMPs and CGRP Receptors.- Regulation of GPCR Trafficking by RAMPs.- Regulation of Calcium Sensing Receptor Trafficking by RAMPs.- Understanding RAMPs through Genetically Engineered Mouse Models.- RAMPs as Drug Targets.- Ramp Like Proteins: RTP and REEP Family of Proteins.- Regulation of RAMP Expression in Diseases.- Perspectives on some Recent Studies on RAMPs.