Pre-eclampsia is one of the leading causes of death and disability in mothers and babies. Over four million women worldwide will develop the disorder every year. This book, written by an international team of experts, focuses on both the scientific basis of pre-eclampsia and its management. The basic science section contains reviews of the most exciting research developments in pre-eclampsia. The clinical chapters provide a comprehensive review of the pertinent literature, highlighting data and ideas or developments in management. There is a section in each chapter (where relevant) that deals with practical management, giving clinicians a formulated treatment plan that they can implement directly. The book was originally published in 2007, and will have continuing relevance for all professionals interested in the reproductive sciences, and to obstetricians and physicians with an interest in pre-eclampsia.
List of contributors; Preface; Part I. Basic Science: 1. Trophoblast invasion in pre-eclampsia and other pregnancy disorders Robert Pijnenborg, Lisbeth Vercruysse, Myriam Hanssens and F. André Van Assche; 2. Development of the utero-placental circulation: purported mechanisms for cytotrophoblast invasion in normal pregnancy and pre-eclampsia Fiona Lyall; 3. In Vitro models for studying pre-eclampsia John Aplin and Ian P. Crocker; 4. Endothelial factors Muna Noori, Mina Savvidou and David Williams; 5. The renin-angiotensin system in pre-eclampsia Fiona Broughton Pipkin; 6. Immunological factors and placentation: implications for pre-eclampsia Ashley Moffett and Susan Hiby; 7. Immunological factors and placentation: implications for pre-eclampsia C. W. G. Redman and I. L. Sargent; 8. The role of oxidative stress in pre-eclampsia M. T. M. Raijmaker and L. Poston; 9. Placental hypoxia, hyperoxia and ischaemia–reperfusion injury in pre-eclampsia Graham Burton, Tai-Ho Hung, and Eric Jauniaux; 10. Tenney–Parker changes and apoptotic versus necrotic shedding of trophoblast in normal pregnancy and pre-eclampsia Peter Kaufmann and Berthold Huppertz; 11. Dyslipidemia and pre-eclampsia Carl A. Hubel; 12. Pre-eclampsia a two-stage disorder: what is the linkage? Are there directed fetal/placental signals? Jim Roberts 13. High altitude and pre-eclampsia Stacy Zamudio; 14. The use of mouse models to explore fetal–maternal interactions underlying pre-eclampsia James C. Cross; 15. Prediction of pre-eclampsia Leslie Myatt and Lavenia B. Carpenter; 16. Long-term implications of pre-eclampsia for maternal health Gordon C. S. Smith; Part II. Clinical Practice: 17. Classification and diagnosis of pre-eclampsia Robyn A. North; 18. Measuring blood pressure in pregnancy and pre-eclampsia Andrew H. Shennan and Annemarie De Greeff; 19. Immune maladaptation in the etiology of pre-eclampsia: an updated epidemiological perspective Gus Dekker and Pierre Yves Robillard; 20. Genetics of pre-eclampsia and counselling the patient who has developed pre-eclampsia Kenneth Ward; 21. Thrombophilias and pre-eclampsia Isobel D. Walker; 22. Medical illness and the risk of pre-eclampsia Catherine Nelson-Piercy; 23. The kidney and pre-eclampsia M. C. Smith and J. M. Davison; 24. Management of mild pre-eclampsia Tracey Glanville and James J. Walker; 25. Management of severe pre-eclampsia Kristin H. Coppage and Baha M. Sibai; 26. The differential diagnosis of pre-eclampsia and eclampsia Michael Varner; 27. Complications of pre-eclampsia Gary A. Dildy III and Michael A. Belfort; 28. Central nervous system findings in pre-eclampsia and eclampsia Diane Twickler and F. Gary Cunningham; 29. Pathogenesis and treatment of eclampsia Joong Shin Park, Michael A. Belfort and Errol R. Norwitz; 30. Anaesthesia for the pre-eclamptic patient Jose M. Rivers and Maya S. Suresh; 31. Critical care management of severe pre-eclampsia John Anthony; 32. The role of maternal and fetal Doppler in pre-eclampsia J. Hornbuckle and S. Robson; 33. Pregnancy-induced hypertension - the effects on the newborn Jonathan Coutts; 34. Medico-legal implications of the diagnosis of pre-eclampsia Jeffrey P. Phelan; Subject Index.