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Photoacoustic Tomography
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Main description:

The concept of photoacoustic tomography (PAT) emerged in the mid-1990s, and the field of PAT is now rapidly moving forward. Presenting the research of a well-respected pioneer and leading expert, Photoacoustic Tomography is a first-of-its-kind book covering the underlying principles and practical applications of PAT in a systematic manner.
Written in a tutorial format, the text: * Addresses the fundamentals of PAT, the theory on photoacoustic effect, image reconstruction methods, and instrumentation * Details advanced methods for quantitative PAT, which allow the recovery of tissue optical absorption coefficient and/or acoustic properties * Explores the development of several image-enhancing schemes, including both software and hardware approaches * Examines array-based PAT systems that are the foundation for the realization of 2-D, 3-D, and 4-D PAT * Discusses photoacoustic microscopy (PAM) and combinations of PAT/PAM with other imaging methods * Considers contrast-agents-based molecular PAT, with both nontargeted and cell receptor-targeted methods * Describes clinical applications and animal studies in breast cancer detection, osteoarthritis diagnosis, seizure localization, intravascular imaging, and image-guided cancer therapy Photoacoustic Tomography is an essential reference for graduate students, researchers, industry professionals, and those who wish to enter this exciting field.


Preface About the Author Fundamentals of Photoacoustic Tomography Photoacoustic Effect Empirical Description Rigorous Theory Image Reconstruction Methods Delay-and-Sum Beam Forming Algorithm Iterative Nonlinear Algorithm A-Line/B-Mode Image Formation Method Instrumentation Quantitative Photoacoustic Tomography Recovery of Optical Absorption Coefficient: Method 1 Recovery of Optical Absorption Coefficient: Method 2 Recovery of Optical Absorption Coefficient: Method 3 Recovery of Optical Absorption Coefficient: Method 4 Simultaneous Recovery of Optical Absorption Coefficient and Acoustic Velocity Multispectral PAT Image Enhancement Software and Hardware Approaches Dual Mesh Scheme Adjoint Sensitivity Method Total-Variation-Minimization Scheme Mathematical Derivations Examples: Reduction of Noise Effect Examples: Image Reconstruction from Few-Detector and Limited-Angle Data Radiative Transfer Equation The RTE and Its Finite Element Discretization The RTE-Based Quantitative PAT Results and Discussion Parallel Computation Variable-Thickness Multilayered Polyvinylidene Fluoride Transducer AlN-Based Piezoelectric Micromachined Ultrasonic Transducer Liquid Acoustic Lens Microelectromechanical Systems Scanning Mirror Photoacoustic Imaging System Results and Discussion Transducer Array-Based Photoacoustic Tomography: 2-D, 3-D, and 4-D Photoacoustic Imaging Array-Based PAT System and 2-D Imaging Laser Source Full-Ring Ultrasound Transducer Array Control Electronics and Data Acquisition System Evaluation and Experimental Studies 3-D Imaging System Description Phantom Experiments In Vivo Experiments 4-D Imaging Drug Delivery Monitoring Tumor Therapy Monitoring Photoacoustic Microscopy and Photoacoustic Computed Microscopy Optical-Resolution Photoacoustic Microscopy Acoustic-Resolution Photoacoustic Microscopy C-Scan Photoacoustic Microscopy Materials and Methods Results and Discussion Photoacoustic Computed Microscopy Methods Results Discussion Photoacoustic Microscopy Based on Acoustic Lens with Variable Focal Length Confocal Photoacoustic Microscopy Using a Single Multifunctional Lens Multimodal Approaches PAT/DOT Material and Methods Results and Discussion PAT/FMT Methods Results and Discussion PAT/Ultrasound Optical-Resolution PAM/OCT Materials and Methods Results and Discussion Contrast-Agents-Based Molecular Photoacoustic Tomography Gold Nanoparticles Graphene Nanosheets Urokinase Plasminogen Activator Receptor (uPAR)-Targeted Magnetic Iron Oxide Nanoparticles (NIR830-ATF-IONP) Material and Methods Results Discussion HER-2/neu Targeted Magnetic Iron Oxide Nanoparticles for Dual-Modal Photoacoustic and Fluorescence Molecular Tomography (PAT/FMT) of Ovarian Cancer Methods Results Discussion Clinical Applications and Animal Studies Joint Imaging 2-D Single-Spectral Quantitative PAT 2-D Multispectral Quantitative PAT 3-D Single-Spectral Quantitative PAT 3-D Multispectral Quantitative PAT Intraoperative Imaging Intraoperative Photoacoustic Tomography (iPAT) System Results and Discussion Brain Imaging Methods Results and Discussion Imaging of Tumor Vasculature Development Methods Results and Discussion Intravascular Imaging Breast Imaging Photoacoustic Tomography System Clinical Experiments Bibliography


ISBN-13: 9781482261042
Publisher: Elsevier (Apple Academic Press Inc.)
Publication date: December, 2014
Pages: 350

Subcategories: Biomedical Engineering, Radiology