This volume is a state-of-the art resource on the recent advances and clinical management of NSAIDs and aspirin. The text provides a thorough overview of NSAIDS and aspirin, reviewing such topics as pharmacology and mechanisms, clinical effects, and the safety and efficacy of these drugs. It also focuses on the effect of the drugs on the cardiovascular system and in the prevention of GI cancer. Practical recommendations for a safe prescription of NSAIDs are also included. Written by experts in the field, NSAIDs and Aspirin: Recent Advances and Implications for Clinical Management is a comprehensive text of great value to gastroenterologists, rheumatologists, cardiologists, oncologists, orthopedists, trauma and internal medicine specialists.
Section 1. Pharmacology and Mechanisms Chapter 1. Chemistry, Pharmacodynamics, and Pharmacokinetics of NSAIDsSara Calatayud and Juan Vicente Esplugues Chapter 2. Principles, Mechanisms of Action, and Future Prospects of Anti-Inflammatory DrugsBibiana Rius and Joan Claria Section 2. Clinical Effects and Drug Safety Chapter 3. Efficacy of NSAIDs in the Treatment of Rheumatic DiseasesMarc C. Hochberg and Lee S. Simon Chapter 4. Adverse Effects of NSAIDs in the Gastrointestinal Tract: Risk Factors of Gastrointestinal Toxicity with NSAIDsSunny H. Wong and Francis K.L. Chan Chapter 5. Adverse Effects of NSAIDs on the Cardiovascular SystemCarmelo Scarpignato and Corrado Blandizzi Chapter 6. Safe Prescription of NSAIDs in Clinical PracticeMohammad Yaghoobi and Richard H. Hunt Section 3. Aspirin Chapter 7. NSAIDS and Aspirin: Recent Advances and Implications for Clinical ManagementKarsten Schror and Michael Voelker Chapter 8. Non-Prescription Analgesic Anti-inflammatory Drugs: Efficacy and SafetyDenis M. McCarthy Chapter 9. Low-Dose Aspirin in the Cardiovascular SystemRuben Casado-Arroyo, Angel Lanas, and Pedro Brugada Chapter 10. Adverse Effects of Low-Dose Aspirin in the Gastrointestinal TractKatsunori Iijima Chapter 11. Aspirin in the Treatment and Prevention of Cardiovascular Disease: Need for Individual Clinical JudgmentsAngel Lanas and Charles H. Hennekens Section 4. NSAIDS and Aspirin in Cancer Prevention Chapter 12. Molecular and Experimental Basis for COX-Inhibition in CancerAnnalisa Bruno, Melania Dovizio, and Paola Patrignani Chapter 13. Clinical Effects of NSAIDs and Coxibs in Colon Cancer PreventionElena Piazuelo and Angel Lanas Chapter 14. Aspirin and the Prevention of Colorectal Cancer Paul J. Lochhead and Andrew T. Chan Chapter 15. A Rational Approach for the Use of NSAIDs and/or Aspirin in Cancer Prevention in the Near Future: "Balancing Risk and Benefits"Elizabeth Half, Ahmad Fokra, and Nadir Arber