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Neurotoxicology, Third Edition
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MORE ABOUT THIS BOOK

Main description:

This new edition presents an integrated approach to neurotoxicology, the study of organisms’ responses to changes in their environment and how interruption of the flow of information by chemical exposure causes a wide range of effects – from learning deficits, sensory disturbances in the extremities, and muscle weakness to seizures and signs similar to neurodegenerative disorders such as Parkinson’s or Alzheimer’s disease.  It is an essential resource for understanding the sites and mechanisms of neurotoxicity, for formulating testable hypotheses about the effects of neurotoxicants, and for improving the risk assessment process. 


Contents:

1. Molecular Approaches to Identify Specific Modes of Action for Neurotoxicity In vitro



Ram Ramabhadran, Steven O. Simmons, William R. Mundy



2. Bioinformatic and Computational Approaches for Analysis of Genomics Data in Neurotoxicology Research


Julia M Gohlke, Willard M. Freeman, Kent E. Vrana



3. Neurotoxicology of Barriers in the Developing Brain


Norman R Saunders, Mark D Habgood, Katarzyna M Dziegielewska



4. Thyroid Hormones – Impact on the Developing Brain: Possible Mechanisms of Neurotoxicity


Mary E. Gilbert, R.T. Zoeller



5. Dopaminergic Nerves as Targets for Neurotoxins


Richard M. Kostrzewa, Lucyna Antkiewicz-Michaluk, Francisco Fornai



6. Endocrine Disruption and Senescence: Consequences for Reproductive Endocrine and Neuroendocrine Systems, Behavioral Responses and Immune Function


Mary Ann Ottinger, Emma Lavoie, Karen Dean, Brandon Sitzmann, Michael J. Quinn, Jr.



7. White Fat Tissue, Obesity, and Possible Role in Neurodegeneration


Palaniyandi Ravanan, Christian Lefebvre d’Hellencourt



8. Microglia: Neuroprotective and Neurodestructive Properties


G. Jean Harry



9. The Slice Culture Model: Considerations for Neurotoxicity Assessment


Andrew D. Kraft



10. Design-Based Stereology and Video Densitometry For Assessment Of Neurotoxicological Damage


P. R. Mouton, M. N. Gordon



11. Effect of Neurotoxins on Brain Tissue and Function Revealed Through in vivo MR Imaging and Spectroscopy


Margaret J. Rosenbloom, Edith V. Sullivan, Adolf Pfefferbaum



12. Principles of Behavioral Phenotyping of Neonatal and Adult Mice


S. H. Brunssen, S. S. Moy, G. E. Kissling


PRODUCT DETAILS

ISBN-13: 9781420054880
Publisher: Taylor & Francis (CRC Press)
Publication date: March, 2010
Pages: 334

Subcategories: Epidemiology, Pharmacology

MEET THE AUTHOR

G. Jean Harry, Ph.D., is Head of the Neurotoxicology Group at the National Institute of Environmental Health Sciences (NIEHS), National Institutes of Health (NIH) and Adjunct Associate Professor at the University of North Carolina (UNC) and Duke University. She obtained an M.S. in PsychoPharmacology from Virginia Commonwealth University (VCU) in 1977 and a Ph.D. in NeuroPharmacology from VCU in 1981. Dr Harry is currently an Associate Editor for Neurotoxicology.


Hugh A. Tilson, Ph.D. received his doctorate in 1971 from the University of Minnesota and postdoctoral training in Pharmacology at Michigan State University. In 2005, Dr. Tilson was named National Program Director for human health research at the Office of Research and Development at the U.S. Environmental Protection Agency. He joined Environmental Health Perspectives as Editor-in-Chief in 2007.