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Nanomaterials in Drug Delivery, Imaging, and Tissue Engineering
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This groundbreaking, multidisciplinary work is one of the first books to cover Nanotheragnostics, the new developmental edge of nanomedicine. Through a collection of authoritative chapters, the book reports on nanoscopic therapeutic systems that incorporate therapeutic agents, molecular targeting, and diagnostic imaging capabilities. An invaluable reference for researchers in materials science, bioengineering, pharmacy, biotechnology, and nanotechnology, this volume features four main parts on biomedical nanomaterials, advanced nanomedicine, nanotheragnostics, and nanoscaffolds technology.


Prefacexv Part I: Biomedical nanomaterials 1Nanoemulsions: Preparation, Stability and Application in Biosciences1 Thomas Delmas, Nicolas Atrux-Tallau, Mathieu Goutayer, SangHoon Han, Jin Woong Kim, and Jerome Bibette 1.1Introduction2 1.2Nanoemulsion:A Thermodynamic Definition and Its Practical Implications5 1.2.1Generalities on Emulsions5 1.2.2Nanoemulsion vs. Microemulsion, a Thermodynamic Definition6 1.3Stable Nanoemulsion Formulation9 1.3.1Nanoemulsion Production9 1.3.2Nanoemulsion Stability Rules11 1.3.3Nanoemulsion Formulation Domain16 1.3.4Conclusion on the Formulation of Stable Nanoemulsions21 1.4Nanoencapsulation in Lipid Nanoparticles21 1.4.1Aim ofActive Encapsulation21 1.4.2Lipid Complexity and Influence of Their Physical State23 1.4.3Amorphous Lipids for a Large Range of Encapsulated Molecules27 1.4.4Lipids Viscosity and Release31 1.4.5Conclusion on the Use ofAmorphous Lipid Matrices for Control OverActive Encapsulation and Release34 1.5Interactions between Nanoemulsions and the Biological Medium: Applications in Biosciences35 1.5.1Nanoemulsion Biocompatibility35 1.5.2Classical TargetingApproach by Chemical Grafting -- Example of Tumor Cell Targeting by Crgd Peptide for Cancer Diagnosis and Therapy38 1.5.3New 'No Synthesis Chemistry'Approach -- Example of Pal-KTTKS andAsiaticoside Targeting for CosmeticActives Delivery41 1.5.4Conclusion on Nanoemulsions Application in Biosciences46 1.6General Conclusion47 References48 2Multifunctional Polymeric Nanostructures for Therapy and Diagnosis57 Angel Contreras-Garcia and Emilio Bucio 2.1Introduction58 2.2Polymeric-based Core-shell Colloid61 2.3Proteins and Peptides64 2.4Drug Conjugates and Complexes with Synthetic Polymers65 2.5Dendrimers, Vesicles, and Micelles67 2.5.1Dendrimers67 2.5.2Vesicles68 2.5.3Micelles70 2.6Smart Nanopolymers71 2.6.1Temperature and pH Stimuli-responsive Nanopolymers72 2.6.2Hydrogels72 2.6.3Stimuli Responsive Biomaterials73 2.6.4Interpenetrating Polymer Networks74 2.7Stimuli Responsive Polymer-metal Nanocomposites 75 2.8Enzyme-responsive Nanoparticles78 Acknowledgements83 References83 3Carbon Nanotubes: Nanotoxicity Testing and Bioapplications97 R. Sharma and S. Kwon 3.1Introduction98 3.1.1What is Nanotoxicity of Nanomaterials?98 3.2Historical Review of Carbon Nanotube99 3.3Carbon Nanotubes (CNTs) and Other Carbon Nanomaterials100 3.3.1Physical Principles of Carbon Nanotube Surface Science102 3.4Motivation -- Combining Nanotechnology and Surface Science with Growing Bioapplications104 3.5Cytotoxicity Measurement and Mechanisms of CNT Toxicity111 3.1.6In Vivo Studies on CNT Toxicity113 3.1.7Inflammatory Mechanism of CNT Cytoxicity114 3.1.8Characterization and Toxicity of SWCNT and MWCNT Carbon Nanotubes116 3.6MSCs Differentiation and Proliferation on Different Types of Scaffolds120 3.6.1An In Vivo Model CNT-Induced Inflammatory Response in Alveolar Co-culture System122 3.6.2Static Model: 3-Dimensional Tissue Engineered Lung124 3.6.3Dynamic Model: Integration of 3D Engineered Tissues into Cyclic Mechanical Strain Device126 3.6.4In Vivo MR Microimaging Technique of Rat Skin Exposed to CNT127 3.7New Lessons on CNT Nanocomposites130 3.8Conclusions135 Part II: Advanced nanomedicine 4Discrete Metalla-Assemblies as Drug Delivery Vectors149 Bruno Therrien 4.1Introduction149 4.2Complex-in-a-Complex Systems150 4.3Encapsulation of Pyrenyl-functionalized Derivatives 155 4.4Exploiting the Enhanced Permeability and Retention Effect159 4.5Incorporation of Photosensitizers in Metalla-assemblies162 4.6Conclusion165 Acknowledgments165 References166 5Nanomaterials for Management of Lung Disorders and Drug Delivery169 Jyothi U. Menon, Aniket S. Wadajkar, Zhiwe iXie, and Kytai T. Nguyen 5.1Lung Structure and Physiology170 5.2Common Lung DiseasesAnd Treatment Methods171 5.2.1Lung Cancer171 5.2.2PulmonaryArterial Hypertension172 5.2.3Obstructive Lung Diseases173 5.3Types of Nanoparticles (NPs)173 5.3.1Liposomes174 5.3.2Micelles176 5.3.3Dendrimers177 5.3.4Polymeric Micro/Nanoparticles177 5.4Methods for Pulmonary Delivery179 5.4.1Nebulization179 5.4.2Metered Dose Inhalation (MDI)182 5.4.3Dry Powder Inhalation (DPI)183 5.4.4IntratrachealAdministration183 5.5Targeting Mechanisms184 5.5.1Passive Targeting184 5.5.2Active Targeting185 5.5.3Cellular Uptake Mechanisms188 5.6TherapeuticAgents Used for Delivery188 5.6.1ChemotherapeuticAgents188 5.6.2Bioactive Molecules190 5.6.3Combinational Therapy190 5.7Applications191 5.7.1Imaging/DiagnosticApplications191 5.7.2TherapeuticApplications193 5.7.3Lung Remodeling and Regeneration194 5.8Design Considerations of NPs195 5.8.1Half-life of NPs195 5.8.2Drug Release Mechanisms195 5.8.3Clearance Mechanisms in the Lung196 5.9Current Challenges and Future Outlook197 6Nano-Sized Calcium Phosphate (CaP) Carriers for Non-Viral Gene/Drug Delivery199 Donghyun Lee, Geunseon Ahn and Prashant N. Kumta 6.1Introduction200 6.2Vectors for Gene Delivery202 6.2.1Viral Vectors203 6.2.2Non-viral Vectors203 6.2.3Calcium Phosphate Vectors205 6.3Modulation of Protection and Release Characteristics of Calcium Phosphate Vector213 6.4Calcium Phosphate Carriers for Drug Delivery Systems219 6.4.1Antibiotics Delivery219 6.4.2Growth Factor Delivery221 6.5Variants of Nano-calcium Phosphates: Future Trends of the CaPDelivery Systems221 Acknowledgements223 References223 7Organics ModifiedMesoporous Silica for Controlled Drug Delivery Systems233 Jingke Fu, Yang Zhao, Yingchun Zhu and Fang Chen 7.1Introduction233 7.2Controlled Drug Delivery Systems Based on Organics Modified 7.2.1MSNs-based Drug Delivery Systems Controlled by Physical Stimuli238 7.2.2MSNs-based Drug Delivery Systems Controlled by Chemical Stimuli246 7.3Conclusions258 References259 Part III: Nanotheragnostics 8Responsive Polymer-Inorganic Hybrid Nanogels for Optical Sensing, Imaging, and Drug Delivery263 Weitai Wu and Shuiqin Zhou 8.1Introduction264 8.2Mechanisms of Response268 8.2.1Reception of an External Signal268 8.2.2Volume Phase Transition of the Hybrid Nanogels275 8.2.4Regulated Drug Delivery282 8.3Synthesis of Responsive Polymer-inorganic Hybrid Nanogels285 8.3.1Synthesis of the Hybrid Nanogels from Pre-synthesized Polymer Nanogels285 8.3.2Synthesis of the Hybrid Nanogels from Pre-synthesized Inorganic NPs289 8.3.3Synthesis of the Hybrid Nanogels by a Heterogeneous Polymerization Method292 8.4Applications293 8.4.1Responsive Polymer-inorganic Hybrid Nanogels in Optical Sensing293 8.4.2Responsive Polymer-inorganic Hybrid Nanogels in Diagnostic Imaging299 8.4.3Responsive Polymer-inorganic Hybrid Nanogels in Drug Delivery301 References306 9Core/Shell Nanoparticles for Drug Delivery and Diagnosis315 Hwanbum Lee, Jae Yeon Kim, Eun Hee Lee, Young In Park, Keun Sang Oh, Kwangmeyung Kim, Ick Chan Kwonand Soon Hong Yuk 9.2Core/Shell NPs from Polymeric Micelles319 9.2.1Polymeric Micelles with Physical Drug Entrapment319 9.2.2Polymeric Micelles with Drug Conjugation321 9.2.3Polymeric Micelles Formed by Temperature-Induced Phase Transition323 9.3Phospholipid-based Core/Shell Nanoparticles325 9.4Layer-by-Layer-Assembled Core/Shell Nanoparticles329 9.5Core/Shell NPs for Diagnosis330 9.4Conclusions331 Acknowledgments331 References331 10Dendrimer Nanoparticles and Their Applications in Biomedicine339 Arghya Paul, Wei Shao, Tom J. Burdon, Dominique Shum-Tim and Satya Prakash 10.1 Introduction340 10.2 Dendrimers and Their Characteristics341 10.3 Biomolecular Interactions of Dendrimer Nanocomplexes343 10.3.1 Genes (siRNA/ANS/DNA)344 10.3.2 Drugs and Pharmaceutics345 10.4 PotentialApplications of Dendrimer in Nanomedicine347 10.4.1 Delivery of Chemotherapeutics347 10.4.2 Delivery of Biomolecules348 10.4.3 Imaging350 10.5 Conclusion353 Acknowledgements355 Indexing words355 References355 11Theranostic Nanoparticles for Cancer Imaging and Therapy363 Mami Murakami, Mark J. Ernsting and Shyh-Dar Li 11.1 Introduction363 11.2 Multifunctional Nanoparticles for Noninvasive 11.2.1 Radiolabeled Nanoparticles 366 11.2.2Fluorescence Imaging of Biodistribution367 11.2.3Multimodal Radiolabel and Fluorescence Imaging of Biodistribution368 11.2.4MRI Imaging of Biodistribution369 11.2.5Multimodal MRI and Fluorescence Imaging of Biodistribution371 11.2.6Multimodal Optical and CT Imaging of Biodistribution372 11.2.7Pharmacokinetics and Pharmacodynamics of Theranostics vs Diagnostics373 11.3 Multifunctional Nanoparticles for Monitoring Drug Release375 11.3.1MRI imaging of Drug Release375 11.3.2Fluorescent Imaging of Drug Release379 11.4 Theranostics to Image Therapeutic Response380 11.5 Conclusion and Future Directions382 Acknowledgement383 References383 Part IV: Nanoscaffolds technology 12Nanostructure Polymers in Function Generating Substitute and Organ Transplants389 S.K. Shukla 12.1 Introduction389 12.2 Important Nanopolymers391 12.2.1Hydrogels393 12.2.2Bioceramics394 12.2.3Bioelastomers395 12.2.4Chitosan and Derivatives396 12.2.5Gelatine396 12.3 MedicalApplications397 12.3.1Tissue Engineering for Function Generating398 12.3.2 Tissue Engineering inArtificial Heart400 12.3.3Tissue Engineering in Nervous System401 12.3.4Bone Transplants404 12.3.5Kidney and Membrane Transplants406 12.3.6Miscellaneous409 Acknowledgement411 References411 13Electrospun Nanofiberfor Three Dimensional Cell Culture417 Yashpal Sharma, Ashutosh Tiwari and Hisatoshi Kobayashi 13.1 Introduction417 13.2 Nanofiber Scaffolds Fabrication Techniques419 13.2.1Self-Assembly419 13.2.2Phase Separation421 13.2.3Electrospinning422 13.3 Parameters of Electrospinning Process424 13.3.1Viscosity or Concentration of the Polymeric Solution424 13.3.2Conductivity and the Charge Density425 13.3.3Molecular Weight of Polymer425 13.3.4Flow Rate425 13.3.5Distance from Tip to Collector425 13.3.6VoltageApplied426 13.3.7Environmental Factors426 13.4 Electrospun Nanofibers for Three-dimensional Cell Culture426 13.5 Conclusions429 References431 14Magnetic Nanoparticles in Tissue Regeneration435 Anuj Tripathi, Jose Savio Melo and Stanislaus Francis D'Souza 14.1 Introduction435 14.2 Magnetic Nanoparticles: Physical Properties438 14.3 Synthesis of Magnetic Nanoparticles440 14.4 Design and Structure of Magnetic Nanoparticles443 14.5 Stability and Functionalization of Magnetic Nanoparticles445 14.6 Cellular Toxicity of Magnetic Nanoparticles450 14.7 Tissue EngineeringApplications of Magnetic Nanoparticles453 14.7.1Magnetofection455 14.7.2Cell-patterning458 14.7.3Magnetic Force-induced Tissue Fabrication461 14.8 Challenges and Future Prospects473 Acknowledgement474 References474 15Core-sheath Fibersfor Regenerative Medicine485 Rajesh Vasita and Fabrizio Gelain 15.1 Introduction486 15.1.1Tissue Engineering487 15.1.2Scaffold Fabrication Technology488 15.2 Core-sheath Nanofiber Technology489 15.2.1Co-axial Electrospinning491 15.2.2Emulsion Electrospinning501 15.2.3Melt Co-axial Electrospinning503 15.3Application of Core-sheath Nanofibers504 15.3.1Delivery of Bioactive Molecules504 15.3.2Tissue Engineering513 15.4 Conclusions519 References519


ISBN-13: 9781118644584
Publisher: John Wiley & Sons Ltd (John Wiley & Sons Inc)
Publication date: March, 2013
Pages: 500

Subcategories: Pharmacology