Mohs surgery is a highly effective treatment for certain cutaneous and oral pharyngeal cancers. The procedure allows for the precise and complete removal of cancers while preserving significant amounts of normal tissue. Through the presentation and orientation of the specimens' complete surgical margin on pathology slides, the location of tumor foci and other relevant findings can be correlated with their locations on the surgical wound. The ability to create perfect slides for histological examination lies at the core of effective Mohs surgery. These procedures have a 99 per cent cure rate for certain cancers when implemented correctly. This book describes the methods the dermatologist, pathologist, or technician can use to optimize the Mohs technique and produce the highest-quality slides and highest cure rates possible.
Part I. Microscopy and Tissue Preparation: 1. Introduction Kenneth G. Gross and Howard K. Steinman; 2. How to excise tissue for optimal sectioning Kenneth G. Gross; 3. Optimizing the Mohs microscope Kenneth G. Gross; 4. Tissue preparation and chromacoding Howard K. Steinman; 5. Embedding techniques Edward H. Yob; Part II. Introduction to Lab Tech Techniques: 6. Lab pearls: how to make great slides and preparing slides with cartilage Alex Lutz and Michael Shelton; 7. Lab pearls: staining, inking, and coverslipping Alex Lutz; 8. Lab pearls: troubleshooting slide quality Alex Lutz; 9. Mohs slide organization and standardization for effective interpretation Kenneth G. Gross; 10. Mohs mapping Howard K. Steinman; Part III. Microanatomy and Neoplastic Disease: 11. Normal microanatomy: vertical & horizontal John Campbell; 12. Basal cell carcinoma: vertical and horizontal A. Neil Crowson and Carlos Garcia; 13. Squamous cell carcinoma: vertical and horizontal A. Neil Crowson and Edward H. Yob; 14. Unusual tumors: vertical and horizontal Terence O'Grady; 15. Mohs for melanoma Adam J. Mamelak and Arash Kimyai-Asadi; 16. Perineural tumors Alexander Miller; Part IV. Special Techniques and Stains: 17. Fixed tissue Mohs Laura T. Cepeda, Daniel Siegel, and Norman Brooks; 18. Tol blue Ofer Arnon, Adam J. Mamelak, and Leonard H. Goldberg; 19. Forms and templates for Mohs surgery Kenneth G. Gross and Howard K. Steinman.