Microbial Biofilms: Omics Biology, Antimicrobials and Clinical Implications is a comprehensive survey of microbial biofilms and their role in human health and disease with contributions from world renowned experts in molecular microbiology, proteomics, genomics, metabolomics and infectious diseases. The book is intended to serve as a guide for students, as well as a reference for researchers, clinicians and industry professionals. The chapters cover bacterial and fungal microbiomes, and the latest omics techniques organized in a clear and up-to-date manner. One of the highlights of this book is the comprehensive information on "omics of microbial biofilms". The chapters dedicated to metagenomics, proteomics and metabolomics are designed to provide a simple and holistic review of the current knowledge and, the applications of these techniques in the field of microbial biofilms. In addition to introductory chapters on microbial biofilms and their clinical implications, subsequent chapters delve into oral biofilms, their composition, and metagenomic diversity.
Thereafter, mechanisms of drug resistance in microbial biofilms are reviewed, as well as the proteomic and metabolomic characterization of this resistance. The book includes a comprehensive discussion of persister cells and host-microbial interactions on mucosal surfaces. Finally, the book concludes with a summary of novel therapeutic approaches for biofilms such as synbiotics and biogenics.
Foreword Preface Contributors Chapter 1 Microbial Biofilms: An Introduction to Their Development, Properties and Clinical Implications Chaminda Jayampath Seneviratne, Neha Srivastava, Intekhab Islam, Kelvin Foong and Finbarr Allen Chapter 2 Clinical Implications of Interkingdom Fungal and Bacterial Biofilms Gordon Ramage, Lindsay E. O'Donnell, Ryan Kean, Eleanor Townsend and Ranjith Rajendran Chapter 3 Oral Biofilms and Their Implication in Oral Diseases Georgios N. Belibasakis and Nagihan Bostanci Chapter 4 Composition and Diversity of Human Oral Microbiome Preethi Balan, Chaminda Jayampath Seneviratne and Wim Crielaard Chapter 5 Candida Biofilms: Properties, Antifungal Resistance and Novel Therapeutic Options Chaminda Jayampath Seneviratne, Thuyen Truong and Yue Wang Chapter 6 Proteomics Approaches to Uncover the Drug Resistance Mechanisms of Microbial Biofilms Chaminda Jayampath Seneviratne, Tanujaa Suriyanarayanan,Lin Qingsong and Juan Antonio Vizcaino Chapter 7 Metabolomics of Microbial Biofilms: Current Status and Future Directions Tanujaa Suriyanarayanan, Chaminda Jayampath Seneviratne, Wei Ling Ng, Shruti Pavagadhi and Sanjay Swarup Chapter 8 Biofilm Persisters: Formation, Molecular Mechanisms and Strategies for Tackling Peng Li, Chaminda Jayampath Seneviratne and Lijian Jin Chapter 9 Host-Biofilm Interactions at Mucosal Surfaces and Implications in Human Health Nityasri Venkiteswaran, Kassapa Ellepola, Chaminda Jayampath Seneviratne, Yuan Kun Lee, Kia Joo Puan and Siew Cheng Wong Chapter 10 Synbiotics, a Fusion of Probiotics and Prebiotics, and Biogenics against Oral Biofilm-Associated Diseases Tomoko Ohshima, Tomomi Kawai, Yukako Kojima, Nobuko Maeda and Chaminda Jayampath Seneviratne Index