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Mathematics as a Laboratory Tool
Dynamics, Delays and Noise
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Main description:

This introductory textbook is based on the premise that the foundation of good science is good data. The educational challenge addressed by this introductory textbook is how to present a sampling of the wide range of mathematical tools available for laboratory research to well-motivated students with a mathematical background limited to an introductory course in calculus.


Uses real data

Uses mathematical methods that are used in the laboratory

Real laboratory exercises provided as supplementary material

Back cover:

The importance of mathematics in the undergraduate biology curriculum is ever increasing, as is the importance of biology within the undergraduate applied mathematics curriculum. This ambitious forward thinking book  strives to make concrete  connections between the two fields at the undergraduate level, bringing in a wide variety of mathematical  methods  such as  signal processing, systems identification, and stochastic differential equations to an undergraduate audience interested in biological dynamics. The presentation stresses a practical hands-on approach: important concepts are introduced using linear first- or second-order differential equations that can be solved using “pencil and paper”; next, these are extended to “real world” applications through the use of computer algorithms written in Scientific Python or similar software.

This book developed from a course taught by Professor John Milton at the University of Chicago and developed and continued over many years with Professor Toru Ohira at the Claremont Colleges. The tone of the book is pedagogical, engaging, accessible, with lots of examples and exercises. The authors attempt to tread a line between accessibility of the text and mathematical exposition. Online laboratories are provided as a teaching aid.  At the beginning of each chapter a number of questions are posed to the reader, and then answered at the conclusion of the chapter.   

 Milton and Ohira’s book is aimed at an undergraduate audience, makes close ties to the laboratory, and includes a range of biological applications, favoring  physiology. This makes it a unique contribution to the literature. This book will be of interest to quantitatively inclined undergraduate biologists, biophysicists and bioengineers and in addition through its focus on techniques actually used by biologists, the authors hope this  text will help shape curricula in biomathematics education going forward.


"Based on the authors' experience teaching biology students, this book introduces a wide range of mathematical techniques in a lively and engaging style.  Examples drawn from the authors' experimental and neurological studies provide a rich source of material for computer laboratories that solidify the concepts.  The book will be an invaluable resource for biology students and scientists interested in practical applications of mathematics to analyze mechanisms of complex biological rhythms."

 (Leon Glass, McGill University, 2013)


Science and the mathematics of black boxes.- The mathematics of change.- Equilibria and steady states.- Stability.- Fixed–points: Creation and destruction.- Transient dynamics.- Frequency domain I: Bode plots and transfer functions.- Frequency domain II: Fourier analysis and power spectra.- Feedback and control systems.- Oscillations.- Beyond limit cycles.- Random perturbations.- Noisy dynamical systems.- Random walkers.- Thermodynamic perspectives.


ISBN-13: 9781461490968
Publisher: Springer (Springer New York)
Publication date: September, 2014
Pages: 492

Subcategories: Neurology


John Milton, Professor of Biology and William R. Kenan Jr Chair n Computational Neuroscience, The Claremont Colleges; Adjunct Professor of Biotechnology, Keck Graduate Institute Toru Ohira, Professor Mathematics, Graduate School of Mathematics, Nagoya University, Japan