The second edition of this work continues to address the intimate pathophysiologic relationship between hypertension and stroke. The editors and authors clearly and concisely synthesize our developing knowledge of this relationship and place epidemiologic and physiologic information into a practical clinical context. Comprehensive chapters present the evidence supporting strategies for stroke prevention and care, including blood pressure lowering therapies, anti-coagulation, and management of other cerebrovascular risk factors. In addition to prescriptive measures for first stroke prevention, the book illuminates current regimens for care immediately after acute stroke and for the prevention of recurrent stroke. This latest edition also features extensively updated chapters from the previous edition, as well as new chapters on the effects of hypertension and stroke on the cerebral vasculature, blood pressure management in subarachnoid hemorrhage, and blood pressure variability, antihypertensive therapy, and stroke risk.
Written by experts in the field, Hypertension and Stroke: Pathophysiology and Management, Second Edition is of great utility for specialists in neurology and cardiovascular medicine and a valuable practical resource for all physicians caring for older adults and hypertensive patients.
I: Blood Pressure and Hypertension as Antecedents of Stroke 1. Blood Pressure: Definition, Diagnosis, and ManagementRaymond R. Townsend and Susan P. Steigerwalt 2. The Link Between Hypertension and Stroke: Summary of Observational Epidemiological StudiesDilip K. Pandey, Noha Aljehani, and Youji Soga 3. Blood Pressure Control and Primary Prevention of Stroke: Summary of Clinical Trial DataWilliam J. Elliott II: Mechanisms of Hypertension and Hypertension-Related Stroke 4. Mechanisms Underlying Essential Hypertension: Neurogenic and Non-neurogenic Scott H. Carlson, Sean Stocker, and J. Michael Wyss 5. The Effects of Hypertension and Stroke on the Cerebral VasculatureAnne M. Dorrance 6. Pathophysiology and Mechanisms Whereby Hypertension May Cause StrokeBeom Joon Kim, Hee-Joon Bae, and Lawrence K. S. Wong III: Management of Blood Pressure for First Stroke Prevention, Immediately after Acute Stroke, and for Recurrent Stroke Prevention 7. Cardiovascular Risk Assessment, Summary of Guidelines for the Management of Hypertension and a Critical Appraisal of the 2014 Expert Panel of the National Institutes of Health ReportLuke J. Laffin and George L. Bakris 8. Acute Blood Pressure Management After Ischemic StrokeJ. Dedrick Jordan and William J. Powers 9. Hypertensive Encephalopathy, Posterior Reversible Encephalopathy Syndrome, and EclampsiaKaren Orjuela and Sean D. Ruland 10. Acute Blood Pressure Management After Intracerebral HemorrhageVenkatesh Aiyagari 11. Blood Pressure Management in Subarachnoid Hemorrhage: The Role of Blood Pressure Manipulation in Prevention of Rebleeding and the Management of VasospasmZakraus K. Mahdavi, Claudia A. Perez, and Michael A. Rubin 12. Recurrent Stroke Prevention I: Diuretic and Angiotensin-Converting Enzyme Inhibitors (ACEIs) - The PROGRESS TrialThomas K. A. Linden and Geoffrey A. Donnan 13. Blood Pressure Variability, Antihypertensive Therapy and Stroke RiskMuhammad U. Farooq, Jiangyong Min, Lawrence K. S. Wong, and Philip B. Gorelick 14. A Review of Antihypertensive Drugs and Choosing the Right Antihypertensive for Recurrent Stroke PreventionDomenic A. Sica IV: Mechanisms and Sequelae of Elevated Blood Pressure on Brain Function and Cognition 15. Vascular Cognitive Impairment and Alzheimer Disease: Are These Disorders Linked to Hypertension and Other Cardiovascular Risk Factors?Fernando D. Testai and Philip B. Gorelick 16. Hypertension, Cerebral Small Vessel Disease, and Cognitive FunctionDavid L. Nyenhuis 17. Cerebral Microbleeds, Small-Vessel Disease of the Brain, Hypertension and CognitionAnand Viswanathan, Hugues Chabriat, and Steven M. Greenberg 18. Neuroimaging of Hypertension and Related Cerebral PathologyAlejandro Magadan