Polycystic ovary syndrome (PCOS) is the most common endocrine disturbance, affecting 10–15% of women in the UK. The definition of PCOS has been much debated, while its pathophysiology appears to be multifactorial and is still being actively researched. There is no doubt that PCOS has a significant effect on quality of life and psychological morbidity and, as many specialists are involved in its management, a multidisciplinary approach is required. The 59th RCOG Study Group brought together a range of experts who treat women with PCOS. This book presents the findings of the Study Group, including: • a definition of PCOS • the accuracy of diagnostic interventions • the particular challenges of adolescent diagnosis and management • the correlation to ethnicity • current approaches to therapy • the potential individualisation of therapy • the role of the alternative therapies used to manage some aspects of PCOS.
1. Overview and definitions of polycystic ovary syndrome and the polycystic ovary Adam Balen; 2. Genetics and pathogenesis of polycystic ovary syndrome Stephen Franks; 3. Ethnic variations in the expression of polycystic ovary syndrome Chandrika N. Wijeyaratne, Vindya Kumarapeli, Ruwanthi de A Seneviratne, Charles N. Antonypillai, S. Rohini de A Seneviratne, G. J. Chaminda Garusinghe, S. Chandrika Yapa and Adam Balen; 4. Quality of life for women with polycystic ovary syndrome Georgina Jones; 5. Insulin resistance, the metabolic syndrome and polycystic ovary syndrome Gerard Conway; 6. Management of polycystic ovary syndrome through puberty and adolescence Rachel Williams and David Dunger; 7. Long-term health risks of polycystic ovary syndrome Didier Dewailly; 8. Approaches to lifestyle management in polycystic ovary syndrome Renato Pasquali and Alessandra Gambineri; 9. Management of obesity in polycystic ovary syndrome, including anti-obesity drugs and bariatric surgery Alexander D Miras and Carel W le Roux; 10. Definition of hyperandrogenism Julian H. Barth, Helen P. Field, Ephia Yasmin and Adam Balen; 11. Treatment of hyperandrogenism in polycystic ovary syndrome Alison M. Layton; 12. Choices in the treatment of anovulatory polycystic ovary syndrome Roy Homburg; 13. Predictors of ovarian response to ovarian stimulation: progress towards individualised treatment in ovulation induction Bart C. J. M. Fauser; 14. Surgical management of anovulatory infertility in polycystic ovary syndrome Adam Balen; 15. The role of insulin-sensitising drugs in the treatment of polycystic ovary syndrome Richard S. Legro; 16. The role of in vitro maturation of oocytes for anovulatory polycystic ovary syndrome Tim Child; 17. Acupuncture and/or herbal therapy as an alternative or complement for relief of polycystic ovary syndrome-related symptoms Elisabet Stener-Victorin; 18. Consensus views arising from the 59th Study Group: Current Management of Polycystic Ovary Syndrome; Index.