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Chromosomal Translocations and Genome Rearrangements in Cancer
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Main description:

This volume collates world experts’ insights into the molecular biology of cancer chromosomes, their abnormalities and the subsequent cellular consequences. Exploring themes involving oncogenes, such as by chromosomal translocations, other genome rearrangements and somatic mutations, this book is a review of the field of cancer genetics that presages a new era, as whole genome sequencing becomes more accessible.

The work begins with a look at historical themes, such as the analysis of metaphase chromosomes using microscopy and staining techniques, advances in which provided our first broad glimpse into the genetic anatomy of a malignant cell. Readers will learn about the application of DNA molecular cloning techniques in the 1980s, that led to the identification of the genes involved in the Philadelphia and Burkitt's lymphoma chromosomal translocations, solidifying the role of oncogenes and tumour suppressor genes in cancer aetiology via chromosomal alterations and which launched a field in cancer genetics.

Subsequent chapters bring the reader up to date by reviewing recent developments in the field, with dedicated sections on leukaemia/lymphoma, sarcomas and epithelial tumours.

Contributions feature numerous colour tables and illustrations and this volume will provide a basis for understanding cancer chromosomes for many years to come.


Back cover:

This volume collates world experts’ insights into the molecular biology of cancer chromosomes, their abnormalities and the subsequent cellular consequences. Exploring themes involving oncogenes, such as by chromosomal translocations, other genome rearrangements and somatic mutations, this book is a review of the field of cancer genetics that presages a new era, as whole genome sequencing becomes more accessible.

 

The work begins with a look at historical themes, such as the analysis of metaphase chromosomes using microscopy and staining techniques, advances in which provided our first broad glimpse into the genetic anatomy of a malignant cell. Readers will learn about the application of DNA molecular cloning techniques in the 1980s, that led to the identification of the genes involved in the Philadelphia and Burkitt's lymphoma chromosomal translocations, solidifying the role of oncogenes and tumour suppressor genes in cancer aetiology via chromosomal alterations, and which launched a field in cancer genetics.

 

Subsequent chapters bring the reader up to date by reviewing recent developments in the field, with dedicated sections on leukaemia/lymphoma, sarcomas and epithelial tumours.

Contributions feature numerous colour tables and illustrations and this volume will provide a basis for understanding cancer chromosomes for many years to come.


Contents:

Part I Introduction 

Chapter 1 -  A short history of chromosome rearrangements and gene fusions in cancer
Felix Mitelman 

Part II General 

Chapter 2 Molecular genetics methods in discovery of chromosome structure
Donna Albertson

Chapter 3 Mechanism of recurrent chromosomal translocations
Fred Alt, Richard Frock, Jiazhi Hu

Chapter 4 Chromosome translocations, cancer initiation and clonal evolution

Mel Greaves, Anthony M Ford 

Chapter 5 Chromosomal fragile sites and cancer
Michelle LeBeau, Yanwen Jiang, Isabelle Lucas

Chapter 6 Copy number changes in carcinomas: applications
Pamela Rabbitts, Henry Wood 

Part III LEUKAEMIA/LYMPHOMA 

Chapter 7  Chronic myeloid leukaemia
Junia Melo, Debora A Casolari

Chapter 8 Immunoglobulin and MYC rearrangements in multiple myeloma pathogenesis
P. Leif Bergsagel, W.Michael Kuehl 

Chapter 9 Genetic alterations in B cell lymphoma
Riccardo Dalla Favera, Marco Fangazio, Laura Pasqualucci 

Chapter 10 Chromosomal translocations and gene rearrangements in acute lymphoblastic leukaemia
Tom Look, Marc Mansour

Chapter 11 Cellular and molecular basis of MLL leukaemias: from transformation mechanisms to novel therapeutic strategies
Chi Wai Eric So, Bernd Zeisig 

Chapter 12 Acute promyelocytic leukaemia:  from a specific translocation to cure by targeted therapies
Hugues de The, Kim Rice 

Chapter 13 Chromosome Abnormalities in AML and their clinical importance
Clara Bloomfield, Krzysztof Mrozek

PART IV SARCOMAS

Chapter 14 Fusion Oncogenes of Sarcomas
Pierre Aman

Chapter 15 Translocations in Ewing Sarcoma
Stephen L Lessnick, Jason M Tanner

PART V EPITHELIAL TUMOURS 

Chapter16 RET and thyroid carcinomas
Giancarlo Vecchio, Maria Domenica Castellone 

Chapter 17 Gene fusions in prostate cancer
Scott Tomlins, A.S.McDaniel 

Chapter 18 Chromosomal Translocations in Lung Cancer
Hiroyuki Mano

Chapter 19 Colon & Ovarian translocations
Paul T. Spellman 

PART VI OTHER ASPECTS 

Chapter 20 Pre-clinical modeling of chromosomal translocations and inversions
Terry Rabbitts, Katia Ruggero 

Chapter 21 Protein complex hierarchy & translocation gene products
Jacqueline Matthews

Chapter 22 Aberrant transcriptional programming in blood cancers
Constanze Bonifer, Peter N. Cockerill, Anetta Ptasinska

Index

 


PRODUCT DETAILS

ISBN-13: 9783319199832
Publisher: Springer (Springer International Publishing)
Publication date: October, 2015
Pages: 390

Subcategories: General Issues, Genetics, Oncology