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Biomarkers in Cancer Screening and Early Detection
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Prepared by world leaders on this topic, Biomarkers in Cancer Screening and Early Detection offers a comprehensive, state-of-the-art perspective on the various research and clinical aspects of cancer biomarkers, from their discovery and development to their validation, clinical utility, and use in developing personalized cancer treatment.
Offers a comprehensive, state-of-the-art perspective on the various research and clinical aspects of cancer biomarkersProvides immediately actionable information and hopefully also inspiration to move discovery and clinical application forwardOffers vital knowledge to help develop personalized cancer treatment for individual patients with specific cancers


List of Contributors, ix
Preface, xiii
Part I Foundations of Biomarker Research
1 Nuts and Bolts of Biomarker Research, 3Sharmistha Ghosh and Sudhir Srivastava
2 Cancer Genome Methylation: Biology, Biomarker and Therapeutic Opportunities, 16Shashwat Sharad, Taduru Sreenath, Shiv Srivastava, and Albert Dobi
3 MicroRNA Biomarkers for Early Detection of Cancer, 27WendyWang, Matthew R Young, and Sudhir Srivastava
4 Inflammation and Cancer, 37Pamela L Beatty, Sandra Cascio, and Olivera J Finn
5 Exosomes: A Valuable Biomedical Tool in Biomarker Discovery and Development, 50Jocelyn Lee, Sharmistha Ghosh, and Sudhir Srivastava
6 Epithelial-to-Mesenchymal Transition (EMT): Clinical Implications, 64Elisa CWoodhouse and Suresh Mohla
Part II State-of-the-Science in Organ-Specific Biomarker Research
7 Breast Cancer, 77Benjamin A Katchman, Christos Patriotis, and Karen S Anderson
8 Ovarian Cancer, 93Christos Patriotis, Archana Simmons, Karen H Lu, Robert C Bast, Jr, and Steven J Skates
9 Esophageal Cancer Biomarkers, 104Yanxin Luo, Kishore Guda, SanfordD Markowitz, Amitabh Chak, Andrew M Kaz, andWilliam M Grady
10 Predictive Biomarkers for Therapy in Adenocarcinoma of the Upper Digestive Tract, 118Heath D Skinner, Qiongrong Chen, Elena Elimova, RoopmaWadhwa, Shumei Song, and Jaffer A Ajani
11 Pancreatic Cancer, 130Sam CWang and Peter J Allen
12 Colon Cancer, 141Paul DWagner
13 Prognostic and Predictive Biomarkers for Colorectal Cancer, 151Upender Manne, Balananda-Dhurjati Kumar Putcha, Temesgen Samuel, and Sudhir Srivastava
14 Early Detection of Lung Cancer, 163Mohamed Hassanein, Melinda C Aldrich, Stephen A Deppen, Karl E Krueger, Eric L Grogan, and Pierre P Massion
15 Commonalities in Lung Cancer and COPD, 185MalgorzataWojtowicz and Eva Szabo
16 Prostate Cancer, 197Jacob Kagan, Ian M Thompson, and DanielWChan
Part III Biomarkers, Screening and Precision Health: Implications for Public Health
17 Improving the Clinical Validity of Biomarker Research in Cancer Detection, 209David F Ransohoff
18 Cancer Overdiagnosis, Ramifications and Research Strategies, 220Barbara K Dunn and Barnett S Kramer
19 Predictive Markers and Driver Genes From Treatment Trials: Potential Utility For Early Diagnosis, 231Brian S Sorg, Sarfraz Memon, Kelly Y Kim, Aniruddha Ganguly, Tracy Lively, James Tricoli, Magdalena Thurin, Lokesh Agrawal, Tawnya C McKee, Barbara A Conley, and J Milburn Jessup
20 Statistical Consideration in Predictive and Prognostic Markers, 245Fei Ye and Yu Shyr
21 Clinical Validation of Molecular Biomarkers in Translational Medicine, 256Harry B Burke and William E Grizzle
22 Cancer Biomarker Assays: Performance Standards, 267Anna K Fuzery and Daniel W Chan
23 Bioethics and Cancer Biomarker Research, 277Nathan Nobis, William Grizzle, and Stephen Sodeke
24 Colon Cancer Screening, 283Molly Perencevich, Jennifer Inra, and Sapna Syngal


ISBN-13: 9781118468821
Publisher: John Wiley & Sons Ltd (John Wiley & Sons Inc)
Publication date: August, 2017
Pages: 480

Subcategories: Medical Diagnosis, Oncology