Main description:

Precision medicine is a topical subject that attracts tremendous attention from scientific and medical communities, being set to transform health care in the future. This book will be among the first to cover the detection methods for precision medicine. The first section provides an overview of the biomarkers used for precision medicine, such as proteins, nucleic acids, and metabolites. The coverage then turns to sequencing techniques and their applications, and other bioanalytical techniques, including mass spectrometry for proteome and phosphoproteome analysis, immunological methods and droplet technologies. The final sections include biosensors applied to precision medicine and clinical applications.

This book provides a reference for researchers and students interested and working in the development of bioanalytical techniques for clinical applications. It provides a useful introduction for physicians and medical laboratory technologists to the recent advances in detection methods for precision medicine.

Contents:

Biomarkers for Precision Medicine: Genome-wide Discovery of MicroRNA Biomarkers for Cancer Precision Medicine; Extracellular vesicles in precision medicine; Proteomics in Precision Medicine; Computational Prediction of Tumor Neoantigen For Precision Oncology; Big Data and its emerging role in therapeutic response modeling; Sequencing Methods in Precision Medicine: Detection of Disease-Associated Mutations and Biomarkers using Next-Generation Sequencing; Nanopore sequencing and detection of tumor mutations; Analytical Challenges of Next Generation Sequencing in Precision Medicine; Single-cell Sequencing of Circulating Tumor Cells: Recent Technical Advances, Challenges and Applications; Other Detection Methods in Precision Medicine: Applications for mass spectrometry-based proteomics and phosphoproteomics in precision medicine; Immunological methods for biomarkers; Droplets technology for precision medicine; POCT for Nucleic Acids by Using Colorimetric Nanoprobes; Clinical Applications in Precision Medicine: Cell Therapy and Immune Therapy; Applications in Precision Oncology