This volume is ideal for individuals interested in taking an in-depth look at how cytokines and chemokines participate in autoimmune disorders, and how cytokines and chemokines can be used as targets for therapeutic intervention. The outstanding features of this book are that it is divided in chapters each focusing on specific, highly prevalent autoimmune disorders. The role of cytokines and chemokines in each of these disorders is dissected in the context of the autoinimune responses that drive these diseases. Importantly, each chapter is meant to provide an in-depth review of how cytokines and chemokines participate in each disease, rather than very specific aspects of cytokine or chemokine biology. The book therefore provides an integrated view of how multiple cytokines and chemokines participate in the initiation and evolution of both systemic and organ-specific pathological immune responses.
Autoimmune diseases and cytokines: pathogenesis and therapy; P. Santamaria. Cytokines, chemokines, their receptors and their genes: an overview; D.J. Kelvin. Cytokine and cytokine receptor genes in the genetic susceptibility and resistance to autoimmunity; R.S. Liblau. Cytokines, lymphocyte homeostasis and self-tolerance; Yiguang Chen. Cytokines as effector mechanisms of tissue destruction in autoimmunity; T.W.H. Kay. Cytokines in the pathogenesis and treatment of experimental autoimmune encephalomyelitis and multiple sclerosis.; D.O. Willenborg. Chemokines in experimental autoimmune encephalomyelitis and multiple sclerosis; T. Owens. Cytokines in the pathogenesis of pancreatic islet graft destruction in autoimmune diabetes; A. Rabinovitch. Chemokines and cytokines in autoimmune diabetes; T.L. Delovitch. Cytokines in the pathogenesis of rheumatoid arthritis and collagen-induced arthritis; E. Lubberts. Chemokines in rheumatoid arthritis; N. Karin. Cytokines and chemokines in virus-induced autoimmunity; M.G. von Herrath. Cytokines in the treatment and prevention of autoimmune responses; T.B. Strom. Cytokines and chemokines in human autoimmune skin disorders (SLE, pemphigus vulgaris); T. Schwarz. Cytokines and chemokines in SLE; F.A. Houssiau. Cytokines in the pathogenesis and treatment of inflammatory bowel disease; L. Steidler.