The rapid advances in radiation oncology, radiation biology, and radiation therapy physics have led to an accumulation of information on the interactions of radiation with other therapeutic modalities, such as the wide array of chemotherapeutic agents being employed in combination with radiation therapy, as well as the multiple biologic response modi? ers that are being used in combination with radiation therapy. It is now recognized that they have a signi? cant impact on normal tissue toxicities. The radiation doses customarily deemed safe on the basis of past experience have now, when combined with other modalities, led to severe late effects in different vital organs. The previously de? ned radiation tolerance dosages remain as valuable guides, but their applicability has changed signi? cantly. The emphasis is now placed on the volume of the organ irradiated, as well as the dose being used. New constructs rel- ing global (whole organ) and focal (partial volume) injury as a function of the dose volume histogram emerge as a signi? cant predictor of late effects on normal tissues. There are now mathematical models such as the model on standard dose, time–dose factors, and accumulated radiation effects that have been supplanted by linear-q- dratic equations using the alpha/beta ratio and its clinical applicability to normal tissue complications. This volume presents contemporary data relating to late effects on normal tissues.
This volume is based on the LENT V NCI-sponsored meeting held in May 2004 and the CURED I conference held in 2006
Written by experts in the field, it addresses a number of critical topics relating to late effects of irradiation, such as mechanisms of injury, the role of screening, intervention options, and second malignancies
Appropriate strategies for prevention and treatment are clearly explained
The search for the most favorable therapeutic ratio – at which ablation of cancer is achieved while normal tissues are conserved – has been modern radiation oncology’s equivalent of the quest for the Holy Grail. Our awareness of the late effects of radiation grew during the past century as new modalities were introduced. Heightened normal tissue reactions accompanied the higher rates of cancer ablation achieved by escalation of radiation doses, accelerated fractionated radiotherapy, and aggressive concurrent chemotherapy and radiation regimens. This volume is based on the LENT V NCI-sponsored meeting held in May 2004 and the CURED I conference held in 2006. Written by experts in the field, it addresses a number of critical topics relating to late effects, such as mechanisms of injury, the role of screening, options for interventions, second malignancies, and prevention. It is hoped that it will assist the reader in understanding how to prevent and treat the long-term side-effects of irradiation.
Radiation (and Medical) Biosurveillance: Screening Survivors for Late Effects of Therapy.- Radiation Biodefense: Medical Countermeasures to Radiation Injury: Science and Service in the Public Interest. A Tribute to Robert Kallman.- Radiation Biopathology: Ionizing Radiation and the Endothelium.- Radiation Biomarkers: Inflammation and Cell Adhesion Molecules are Involved in Radiation-Induced Lung Injury.- Radiation Biomechanisms: Volume Effects in Radiation Damage to Rat Lung.- Radiation Bioimaging: The Role of Imaging in the Study of Radiation-Induced Normal Tissue Injury.- Radiation Biophysiology: Screening for Cardiovascular Disease in Survivors of Thoracic Radiation.- Radiation Biointervention: Hypoxia Mediated Chronic Normal Tissue Injury: A New Paradigm and Potential. Strategies for Intervention.- Radiation Bioprevention: Prevention and Treatment of Radiation Injuries: The Role of the Renin-Angiotensin System.- Radiation Bioepidemiology: Second Malignancies as a Consequence of Radiation Therapy.- Radiation Bioinformatics: Using Quality of Life Information to Rationally Incorporate Normal Tissue Effects into Treatment Plan Evaluation and Scoring.- Radiation Bioscoring: Cancer-Related Fatigue as a Late Effect: Severity in Relation to Diagnosis, Therapy, and Related Symptoms.- Radiation Biotoxicity Taxonomy: A Normal Tissue TNM Toxicity Taxonomy: Scoring the Adverse Effects of Cancer Treatment.- Radiation Biocontinuum: Follow-Up Care For Cancer Survivors: Needs, Issues, and Strategies.