Main description:

First published in 1979, Chemical Carcinogenesis and DNA is an essential guide to the relationship between mutagens, carcinogens and our own genetic makeup. Covering a range of associated topics, this volume provides information that would prove most beneficial for practitioners of medicine and students alike.

Contents:

Volume 1. Chapter 1. Approaches to Chemical Dosimetry in Mutagenesis and Carcinogenesis: The Relevance of Reactions of Chemical Mutagens and Carcinogens with DNA. 1. Chapter 2. In Vitro Modification of Nucleic Acids by Indirect-Acting Chemical Carcinogens. 37. Chapter 3. The Use of Radioactive Carcinogens to Detect DNA Modifications. 59. Chapter 4. Fluorimetric Detection of DNA-Carcinogen Complexes. 85. Chapter 5. Nucleic Acid Modification by N-Nitroso Compounds. 111. Chapter 6. Carcinogenic Plant Products and DNA. 161. Chapter 7. Fungal Toxins, Aflatoxins, and Nucleic Acids. 187. Index. 227

Volume 2. Chapter 1. Metabolic Activation of Aromatic Amines and Amides and Interactions with Nucleic Acids. 1. Chapter 2. Polycyclic Aromatic Hydrocarbon Metabolites: Their Reactions with Nucleic Acids. 29. Chapter 3. Conformational Changes in Nucleic Acids Modified by Chemical Carcinogens. 59. Chapter 4. Mutagenic Consequences of Chemical Reaction with DNA. 95. Chapter 5. Repair and Carcinogenesis. 133. Chapter 6. DNA - The Critical Cellular Target in Chemical Carcinogenesis? 159. Chapter 7. Chemical Carcinogenesis as a Consequence of Alterations in the Structure and function of DNA. 181. Index. 201.