(To see other currencies, click on price)
MORE ABOUT THIS BOOK
Main description:
A critical review our current understanding of camptothecins, their shortcomings, and of the possibilities for improving their clinical performance. The authors discuss new camptothecin analog development, drug delivery issues for optimizing their anticancer activity, and their potential use in a variety of different cancers. Additional chapters describe what is known about the biochemistry, the pharmacology, and the chemistry of the camptothecins, including the mechanism of topoisomerase and how camptothecins poison this enzyme, the use of animal models in defining the anticancer potential of camptothecins, and the question of camptothecin resistance.
Contents:
Part I: Biochemistry, Pharmacology, and Chemistry
Mechanism of Action of Topoisomerase 1 Poisons
Leroy F. Liu and Shyamal D. Desai
Crystallographic Insight Into the Mechanism of Drug-Induced Topoisomerase I DNA Damage
Alex B. Burgin, Jr., Michael D. Feese, Bart L. Staker, and Lance Stewart
Inhibitors of Topoisomerase I Function
Sidney M. Hecht
Cytotoxic Mechanisms of the Topoisomerase 1 Inhibitors
Yves G. Pommier, Juana Barcelo, Takahisa Furuta, Haruyuki Takemura, Olivier Sordet, and ZhiYong Liao
Biochemical and Genetic Analyses of DNA Topoisomerase 1-Mediated DNA Damage
Robert C. A. M. van Waardenburg and Mary-Ann Bjornsti
Preclinical Models for Evaluating Topoisomerase I-Targeted Drugs
Aarti S. Juvekar, Joyce Thompson, Clinton F. Stewart, and Peter J. Houghton
Mechanisms of Resistance to Camptothecins
Zeshaan A. Rasheed and Eric H. Rubin
Recent Advances in Camptothecin Drug Design and Delivery Strategies
Thomas G. Burke, Tian-Xiang Xiang, Bradley D. Anderson, and Lori J. Latus
Part II: Clinical Perspectives
Clinical Experience With 9-Aminocamptothecin: Lessons for New Drug Development
Chris H. Takimoto
Clinical Studies of Rubitecan (9-Nitro 20(S) Camptothecin)
Hilary Hewes, Judith A. Smith, and Claire Verschraegen
Irinotecan: Current Clinical Status and Pharmacological Aspects
Laurent P. Rivory
Clinical Experience With Topotecan
Aimee K. Bence and Val R. Adams
The Clinical Development of Lurtotecan: Experience With Water-Soluble and Liposomal Forms
Keith T. Flaherty, James P. Stevenson, Christopher J. Twelves, and Peter J. O'Dwyer
Preclinical and Clinical Development of Exatecan (DX-8951f): A Hexacyclic Camptothecin Analog
Eric K. Rowinsky
Camptothecins in the Treatment of Primary Brain Tumors
Clinton F. Stewart,Markos Leggas, and Henry S. Friedman
Camptothecins in the Treatment of Lung Cancer
Pankaj Kumar, Missak Haigentz, Jr., Jorge Gomez, and Roman Perez-Soler
Use of Camptothecins in the Treatment of Leukemia and Related Disorders
Benjamin M. F. Mow and Scott H. Kaufmann
Index
PRODUCT DETAILS
Publisher: Springer (Humana Press Inc.)
Publication date: November, 2014
Pages: 476
Weight: 724g
Availability: Available
Subcategories: Oncology
From the same series
Nicola Curtin
Jorge J. Castillo
Moulay A. Alaoui-Jamali
Gail Lewis Phillips
Frank E. Koehn
Beverly A. Teicher
Gary J. Kelloff
Ryan J. Sullivan
Gary K Schwartz
Antonio Tito Fojo
William D. Figg
Steven Kanner
Giovanni Melillo
Masaki Terabe
Yves Pommier
Derek LeRoith
Beverly A. Teicher
Ann L. Jackman
Jorge J. Castillo
Manuel Hidalgo
Vinata B. Lokeshwar
Beverly A. Teicher
Moulay A. Alaoui-Jamali
Saïd M. Sebti
Frank E. Koehn
Rebecca G. Bagley
Vitaly A. Polunovsky
Benjamin Bonavida
Beverly A. Teicher
Alan M. Gewirtz
Michael A Morse
Janusz W. Rak
J. Silvio Gutkind
Maryann Foote
Zahid H. Siddik
L. Harivardhan Reddy
Gavin J. Gordon
Masaki Terabe
Yves Pommier
Derek LeRoith
Neil J. Clendeninn
Howard L. Kaufman
John D. Haley
Manuel Hidalgo
Beverly A. Teicher
Ulrike Stein
Pat Price
Kelly K. Hunt
Mary L. Disis
David A. Gewirtz
Beverly A. Teicher
Sayed S. Daoud
Nicholas P. Farrell
Vinata B. Lokeshwar
Beverly A. Teicher
Giampietro Gasparini
Doriano Fabbro
Nicholas B. La Thangue
David E. Fisher
Beverly A. Teicher
John A. Hickman
Godefridus J. Peters
Julian Adams
Sonia Jakowlew
Antonio Giordano
Youcef M. Rustum
Michel Page
Gurmit Singh
Gary J. Kelloff
Moulay A. Alaoui-Jamali
Wafik S. El-Deiry
Keiko Hiyama
Amy M. Fulton
Federico Innocenti
Hak Choy
Sonia Jakowlew
Dennis M. Brown
Michael T. Lotze
Randall E. Harris
Eric Verdin
Benjamin Bonavida
Rebecca G. Bagley
Vitaly A. Polunovsky
Benjamin Bonavida
L. Harivardhan Reddy
V. Craig Jordan
Zahid H. Siddik
Erwin G. van Meir
Amy M. Fulton
Beverly A. Teicher
Keiko Hiyama
Gavin J. Gordon
David S. Ettinger
Federico Innocenti
John D. Haley
Benjamin Bonavida
Antonio Tito Fojo
Sonia Jakowlew
Sonia Jakowlew
Howard L. Kaufman
David A. Gewirtz
Beverly A. Teicher
Sayed S. Daoud
Pat Price
Michael T. Lotze
Ulrike Stein
Kelly K. Hunt
Godefridus J. Peters
Beverly A. Teicher
Eric Verdin