Main description:

A significant new book on drug delivery to the eye
Biopharmaceutics of Ocular Drug Delivery examines the current physiological, anatomical, pharmaceutical/technological, and biopharmaceutical knowledge on ocular drug delivery. Leading ophthalmic researchers cover topics such as the formulation and usage of ophthalmic solutions and suspensions, the influence of surfactants and preservatives on ocular drug absorption, and new techniques that include bioadhesion and the use of hyaluronic acid as an ophthalmic vehicle. Promising research on new delivery systems for improved drug therapy is highlighted, including new pharmaceutical vehicles, inserts, liposomes, nanoparticles, and prodrugs.

Biopharmaceutics of Ocular Drug Delivery is one of the few books available on drug delivery to the eye and will be an important reference for ophthalmologists, pharmacologists, pharmaceutical researchers, and other scientists interested in the topic.

Contents:

Anatomy and Physiology of the Eye. Physiological Aspects of Ocular Drug Therapy (Johan Stjernschantz and Maria Astin). Formulation of Ophthalmic Solutions and Suspensions. Problems and Advantages (Marc M.M. Van Ooteghem). The Effects of Preservatives on Corneal Permeability of Drugs (Keith Green). Solid Polymeric Inserts/Disks as Drug Delivery Devices (Marco Fabrizio Saettone). The Development and Use of In Situ Formed Gels, Triggered by pH (Robert Gurny, Houssam Ibrahim, and Pierre Buri). Liposomes and Nanoparticles as Ocular Drug Delivery Systems (Michael Mezei and Dale Meisner). Use of Hyaluronic Acid in Ocular Therapy (Stephanie R. Bernatchez, Ola Camber, Cyrus Tabatabay, and Robert Gurny). Improved Ocular Drug Delivery by Use of Chemical Modification (Prodrugs) (Vincent H. L. Lee). Bioadhesives in Ocular Drug Delivery (Eliot M. Slovin and Joseph R. Robinson). Pharmacokinetics in Ocular Drug Delivery (Ronald D. Schoenwald). Index.

c. 224 pp., 7x10, due November 1992, ISBN 0-8493-7296-8.