Main description:

Since its first edition in 1975, this extraordinary textbook has helped shape the way that biochemistry is taught, and has become one of the most trusted books in the field. It offers exceptionally clear writing, innovative graphics, coverage of the latest research techniques and advances, and a signature emphasis on physiological and medical relevance. The seventh edition has been updated throughout, including many new advances on genetic regulation, and revamped coverage of the integration of metabolism in the context of diet and obesity. Numerous new medical examples have been added throughout to make biochemistry real and relevant to students. The addition of new contributing author Gregory Gatto, an active pharmaceutical researcher at GlaxoSmithKline, ensures that the seventh edition presents the latest techniques that students need to understand in biochemistry research today. The end-of-chapter problems have also been revised and updated, providing students with great new exercises to test their understanding. The book is supported by a companion website (www.whfreeman.com/berg7e) which provides a variety of tools to aid understanding and learning including concept-based tutorials, animated techniques, self-assessment tools, and living figures that allow protein structures to be explored in 3-D.

Contents:

PART I: THE MOLECULAR DESIGN OF LIFE Biochemistry: An Evolving Science Protein Composition and Structure Exploring Proteins and Proteomes DNA, RNA, and the Flow of Genetic Information Exploring Genes and Genomes Exploring Evolution and Bioinformatics Hemoglobin: Portrait of a Protein in Action Enzymes: Basic Concepts and Kinetics Catalytic Strategies Regulatory Strategies Carbohydrates Lipids and Cell Membranes Membrane Channels and Pumps Signal-Transduction Pathways PART II: TRANSDUCING AND STORING ENERGY Metabolism: Basic Concepts and Design Glycolysis and Gluconeogenesis The Citric Acid Cycle Oxidative Phosphorylation The Light Reactions of Photosynthesis The Calvin Cycle and the Pentose Phosphate Pathway Glycogen Metabolism Fatty Acid Metabolism Protein Turnover and Amino Acid Catabolism PART III: SYNTHESIZING THE MOLECULES OF LIFE The Biosynthesis of Amino Acids Nucleotide Biosynthesis The Biosynthesis of Membrane Lipids and Steroids The Integration of Metabolism DNA Replication, Repair, and Recombination RNA Synthesis and Processing Protein Synthesis The Control of Gene Expression in Prokaryotes The Control of Gene Expression in Eukaryotes PART IV: RESPONDING TO ENVIRONMENTAL CHANGES Sensory Systems The Immune System Molecular Motors Drug Development