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Animal Models of Brain Tumors
Series: Neuromethods
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Main description:

Although the available models, whether at the cellular, tissue, or animal level, do not exactly represent the biology of human brain tumors, animal models can offer significant insights into these tumors, providing a better understanding of biological mechanisms underlying tumor generation, growth, angiogenesis, invasion, and metastasis. Animal Models of Brain Tumors brings together developments and discoveries in "in vivo" experimental tumor research that have provided advances in our understanding of the cellular and molecular mechanisms involved in the generation, progression, and clinical outcome of brain neoplasms. Broken into convenient sections, this thorough volume includes topics such as animal model insights into human brain neoplasms, the cellular, molecular, and genetic basis of brain tumors, therapies in the treatment of malignant glioma, as well as imaging technologies in animal tumor models, i.e. measuring brain tumor growth and metabolism. Written for the popular Neuromethods series, chapters include the kind of detailed description and implementation advice that is essential for achieving successful results.

Authoritative and cutting-edge, Animal Models of Brain Tumors provides the key methods needed to validate, compare, and contrast the animal model with its proposed human counterpart and further the understanding of our own serious ailments.


Contents:

Part I: Introduction

Brain Tumor Models to Predict Clinical Outcome: Like the Phoenix?

Lois A. Lampson

Animal Models in Cancer Research: Assessment of Severity and the Application of Humane Endpoints

Jose M. Orellana-Muriana

Part II: Animal Models Offer Insights into Human Brain Neoplasms

The VM Mouse Model of Glioblastoma Multiforme

Thomas N. Seyfried, Laura M. Shelton, and Leanne C. Huysentruyt

Oligodendroglioma Models

Nanna Lindberg and Lene Uhrbom

Medulloblastoma Model

Jasmine Lau and William A. Weiss

Learning about Retinoblastoma from Mouse Models that Missed

David Cobrinik

Ependymoma Models

Jesus Vaquero and Mercedes Zurita

Meningioma Models

Jessica Rainey and Randy L. Jensen

Pituitary Models

Walavan Sivakumar and William T. Couldwell

Growth Regulation of Nervous System Tumors: Models for Assessment of Angiogenesis in Brain Tumors

Kelly Burrell, Elena Bogdanovic, Shahrzad Jalali, Gelareh Zadeh, and Abhijit Guha

Part III: Cellular, Molecular, and Genetic Basis of Brain Tumors: Data from Animal Models

Using Genetically-Engineered Mouse Models to Understand Low-Grade Glioma Development and Growth in Children

Aparna Kaul, Ibrahim Hussain, and David H. Gutmann

EGFR and Tumor-Suppressor Function in Brain Cancer Development

Julie Lessard and Al Charest

Part IV: Therapies in the Treatment of Malignant Glioma: Data from Animal Models

Rodent Glioma Models: Intracranial Stereotactic Allografts and Xenografts

Hikmat Assi, Marianela Candolfi, Pedro R. Lowenstein, and Maria G. Castro

Immunotherapy of High-Grade Gliomas: Preclinical In Vivo Experiments in Animal Models

Kristen A. Batich, Bryan D. Choi, and Duane A. Mitchell

Assessing Mechanisms of Glioblastoma Invasion

Stephen M. Robbins and Donna L. Senger

Part V: Imaging Technologies in Animal Tumor Models: Measuring Brain Tumor Growth and Metabolism

Positron Emission Tomography (PET)-Based Molecular Imaging

Yannic Waerzeggers, Thomas Viel, Sonja Schafers, Stefan Wagner, Andreas Faust, Burkhard Riemann, Klaus Kopka, Otmar Schober, Klaus Schafers, and Andreas H. Jacobs

In Vivo Magnetic Resonance Spectroscopic Imaging (MRSI) and Ex Vivo Quantitative Neuropathology by High Resolution Magic Angle Spinning Proton Magnetic Resonance Spectroscopy (HRMAS)

Rui V. Simoes, Ana Paula Candiota, Margarida Julia-Sape, and Carles Arus

Single Photon Emission Computed Tomography (SPECT) in Small Animal CNS Research

Andre Constantinesco, Christian Goetz, and Philippe Choquet


PRODUCT DETAILS

ISBN-13: 9781627032087
Publisher: Springer (Humana Press Inc.)
Publication date: November, 2012
Pages: 390
Weight: 9992g
Availability: Available
Subcategories: Neurology, Neuroscience
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