The revision of this definitive, two-volume reference work is dedicated to the maintenance of a comprehensive approach to the practice of pediatric gastroenterology. The text of the fifth edition was extensively reviewed to assess the continuing relevance and, as a result, the size and content of various sections have been modified and new chapters have been added. Each author, selected because of particular expertise in the field, has provided an authoritative and comprehensive account of his or her topic. In addition, new sections have been added to reflect the expanding complexity of the field, particularly new techniques now used to accurately establish complex diagnoses. As with previous editions, the size and content of each section has been modified and new chapters added to reflect an increasing evolution of subspecialty programs within gastroenterology and a better understanding of subspecialty conditions (motility, inflammation, and autoimmune bowel disease) that have emerged in pediatric gastroenterology.
As the importance of genetics and molecular biology in the pathophysiology and diagnosis of complex pediatric conditions of the gut, pancreas, and liver have become appreciated, expanded chapters cover their importance in the field. Furthermore, a more comprehensive representation of world leaders in pediatric gastroenterology among the editors of this edition has expanded the authorship to reflect experts in specific diseases within various continents rather than principally in North America. In other words, the edition is dedicated to a comprehensive, worldwide approach to the practice of pediatric gastroenterology.
* SECTION I: MOUTH AND ESOPHAGUS * Anatomy, Embryology, and Congenital Anomalies of the Mouth and Esophagus: Jonathan E. Teitelbaum * Disorders of the Oral Cavity: Stephen R. Porter, Paul Ashley * Disorders of Deglutition: David N. Tuchman * Esophageal Motility * Normal Motility and Development of the Esophageal Neuroenteric System: Salvatore Cucchiara, Giovanni Di Nardo, and Salvatore Oliva * Gastroesophageal Reflux: Collin Rudolph, Eric Hassall * Other Esophageal Neuromuscular Disorders: Benjamin D. Gold * Esophagitis: Mike Thomson * Toxic and Traumatic Injury of the Esophagus: Emmanuel Mas, Anne Breton, Jean-Pierre Olives * SECTION II: THE STOMACH AND DUODENUM * Anatomy, Embryology, and Congenital Anomalies: Sanne Rosekrans, Nike V.J.A. Buller, Nikhil Thapar, Gijs R. van den Brink * Nausea and Vomiting (including Pyloric Stenosis): B. Li, Katja Kovacic * Gastritis: Helicobacter pylori and Peptic Ulcer Disease: Marion Rowland, Billy Bourke, Brendan Drumm * Acid-Peptic Disease: Frederic Gottrand * Other Causes of Gastritis: C. Y. Ooi, D. A. Lemberg, Andrew S. Day * Esophageal and Gastric Neoplasms: Robert Riddell, David Schaeffer * Development of the Gastric Neuroenteric System * Normal Motility and Development of the Gastric Neuroenteric System: Miguel Saps, Carlo Di Lorenzo * Motility Disorders: Miguel Saps, Carlo Di Lorenzo * SECTION III: THE INTESTINE * Anatomy and Embryology: Pascal De Santa Barbara * Congenital Anomalies Including Hernias: David Lloyd, Simon Edward Kenny, David Wilkinson * Lymphatic Disorders: Pierre Yves Vonder Weid, Decker Butzner * Absorption and Digestion * Normal Physiology: Jean Pierre Cezard * Acute Diarrhea: Stephano Guandalini * Persistent and Chronic Diarrhea: Alfredo Guarino, Roberto Berni Cancani * Genetically Determined Disaccharidase Deficiency: Hassan Y. Naim, Mahdi Amiri, Klaus-Peter Zimmer * Congenital Intestinal Transport Defects: Martin G. Martin, Ernest M. Wright * Congenital Enteropathies: Olivier Goulet, Julie Salomon * Immune Enteropathies * Celiac Disease: Alessio Fasano * Eosinophilic Esophagitis: Clies Menard-Katcher, Chris Liacouras, Vincent Mukkada, Glenn Furuta, Marc Rothenberg * Allergic Enteropathy: Franco Torrente, Simon Murch * Autoimmune Enteropathy and IPEX Syndrome: Frank M. Ruemmele, Nicole Brousse, Olivier Goulet * Surgical Disorders * Intestinal Obstructions: Brad Warner, Elizabeth Fialkowski * Appendicitis: Kevin N. Johnson, Craig Egan, Dennis P. Lund * The Pediatric Ostomy: Catherine Cord-Udy * Perianal Lesions: Sidney Johnson, Tom Jaksic * Microbial Interactions with Gut Epithelium: Nicola L. Jones, Eytan Wine, Seamus Hussey * Modulation of the Intestinal Flora * Probiotics: David Mack * Prebiotics, Symbiotics, and Fermented Products: Glenn Gibson * Antimicrobials: Michael R. Millar, Mark Wilks * Infections * Bacterial Infections, Food and Waterborne Infections: Mitchell Cohen * Viral Infections: Dorsey M. Bass * Parasitic and Fungal Infections: Michael Farthing, Paul Kelly, Beatrice Amudi * Immune and Inflammatory Disorders * Immunology Adaptive and Innate: James Chen * Immunodeficiency and the Intestine, Including GI Manifestations of Primary Immunodeficiency Diseases: Delane Shingadia, Amel Hassan * Necrotizing Enterocolitis: Erika C. Claud, Michael Caplan * Cronic Inflammatory Bowel Disease * Crohn's Disease: Anne M. Griffiths, Jean-Pierre Hugot * Ulcerative and Indeterminate Colitis: Nick Croft * Atypical Colitis and Other Inflammatory Disease: Barbara A. Kirschner, Ranjana Gokhale * Surgical Aspects: Jacob C. Langer * Peritonitis: Ori Rotstein, David Hackam * Intestinal Failure * Short Bowel Syndrome: Yigal Finkel, John Puntis * Intestinal Failure: Associated Liver Disease: Julie E. Bines, Prue Pereira-Fantini * Small Intestinal Transplantation: Stuart S. Kaufman * Intestinal Tumors * Intestinal Polyps and Polyposis: Jean-Francois Mougenot, Sylviane Olschwang, Michel Peuchmaur * Other Neoplasms: Kamran Badizadegan, Rhea J. Birusingh * Intestinal Motility * Normal Motility and Development of the Intestinal Neuroenteric System: Annamaria Staiano, Massimo Martinelli * Motility Disorders * Idiopathic Constipation: Aliye Uc, Riad Rahhal * Hirschsprung Disease: Cheryl Gaiepy, Steven L. Ciciora * Other Dysmotilities Including Chronic Intestinal Pseudo-obstruction Syndrome: Jaime Belkind-Gerson * IBS Including Colic, Gas, and Abdominal Pain: Mark Benninga * Gastrointestinal Aspects of Systemic Endocrinopathies: Yaron Avitzur, Karolina Burkhardt * Bowel Injury * Drug-Induced Bowel Injury: Shinya Ito * Radiation-Induced Bowel Injury: Agnes Francois * SECTION IV. THE LIVER * Anatomy and Embryology: Mark Davenport * Physiology * Bile Formation and Cholestasis: Saul Karpen * Bilirubin Metabolism: Glenn R. Gourley * Fibrogenesis and Cirrhosis: Ross W. Shepherd * Normal Hepatocyte Function and Mechanisms of Dysfunction: Ira Fox * Diagnostic Approaches to Common Pediatric Liver Problems: Etienne Sokal * Disorders of the Biliary Tract * Disorders of the Intrahepatic Ducts: Ekkhard Sturm * Biliary Atresia: Kathleen M. Campbell, Jorge A Bezerra * Sclerosing Cholangitis: Dennis Black * Choledocal Cysts and Other Biliary Disorders: Philip Rosenthal * Infections Viral Infections * Hepatitis B Virus: Mei-Wei Chang * Hepatitis C Virus: Daniel Leung * Other Viral Infections: Jaime Chu, Ronen Arnon * Bacterial, Parasitic, and Other Infections: Dinesh Pashankar, Richard A. Shreiber * Immune Deficiency and the Liver: Collin Ball, Dino Hadzic * Autoimmune Disease: Diego Vergani, Marianne Samyn * Drug-Induced Hepatotoxicity: Eve A. Roberts * Liver Tumors: Milton Finegold, Joel E. Haas * Genetic and Metabolic Disorders * Genetic Testing in Clinical Practice: Nancy Spinner * Carbohydrate Metabolism: Simon Horslen * Amino Acid Metabolism: Karen F. Murray, Amy C. Tsai * Disorders of Mitochondrial and Fatty Acid Metabolism: Roshni Vara *?1-Antitrypsin Deficiency: David H. Perlmutter * Zelleweger Syndrome and Other Disorders of Proximal Metabolism: Steven Steinberg, Gerald V. Raymond, Paul A. Watkins * Lysosomal Acid Lypase Deficiencies: Wolman Disease and Cholestyrl Ester Storage * Disease: Gregory A. Grebowski, Kevin Bove, Hong Du * Wilson Disease: Stuart Tanner * Iron Storage Diseases: Peter Whitington, Paul Adams * Biliary Transport: Laura Bull, Lee Bass * Bile Acid Synthesis Disorders: Ken Setchell, James Heubi * Fatty Liver Disease: Valerio Nobili * Systemic Conditions Affecting the Liver: Samar Ibrahim, Deborah Freese, Mounif El-Youssef * Acute Liver Failure: Sanjay Bansal, Anil Dhawan * Treatement of End-Stage Liver Disease: Suzanne McDiarmid * Liver Transplantation: Hector Vilca-Melendez * Gallbladder Disease: Annemarie Broderick, Brian T. Sweeney * SECTION V: THE PANCREAS * Congenital Anomalies, Including Embryology, Anatomy, and Physiology: Dominique M. Jan * Tumors: Michael Hii, Assad M. Butt * Pancreatitis * Acute and Chronic Pancreatitis: David C. Whitcomb, Mark E. Lowe * Juvenile Tropical Pancreatitis: S. Pitchumoni, Viswanathan Mohan * Exocrine Pancreatic Dysfunction * Cystic Fibrosis: Michael Wilschanski * Shwachman-Diamond Syndrome: Peter R. Durie * Other Hereditary and Acquired Pancreatic Disorders: Michael Wilschanski * SECTION VI: DIAGNOSIS OF GASTROINTESTINAL DISORDERS * Gastrointestinal Endoscopy * Patient Preparation and General Considerations: Victor L. Fox * Upper Gastrointestinal Endoscopy: Simon Murch * Upper Gastrointestinal Bleeding: Mark A. Gilger, K. Lynette Whitfield Van Buren * Ileocolonoscopy and Enteroscopy: Mike Thomson * Lower Gastrointestinal Bleeding: Dominique Turck, Laurent Michaud * Gastrointestinal Endosonography: Victor L. Fox * Endoscopic Retrograde Cholangiopancreatography: Claude Liguory, Francois Mougenot, Andrade de Paulo * Interventional Endoscopy: Recent Innovations: Mike Thomson * Liver Biopsy Interpretation: A.S. Knisely * Intestinal Biopsy: Alan David Phillips, Virpi V. Smith * Gastrointestinal Manometry: Methodology and Indications: Samuel Nurko * Esophageal pH and Impedance Measurement: Yvan Vandenplas, Silvia Salvatore * Imaging * Imaging of Gastrointestinal Tract Disease: Debra Gervais, Michael Gee * Cross-Sectional Imaging: Ultrasonography, Computed Tomography, Magnetic Resonance Imaging---Including Abdominal Masses and MRCP: Debra Gervais, Michael Gee * Interventional Gastrointestinal Radiography: Debra Gervais, Michael Gee * Radionucleotide Diagnosis: Martin Charron, Reza Vali * SECTION VII. PSYCHOSOCIAL ASPECTS OF GASTROINTESTINAL DISORDERS * Gastrointestinal Features of Pediatric Illness Falsification: Paul Hyman, Brenda Bursch * Psychological Aspects of Chronic Disease: Steve Shlozman, Suzanne Bender * Adherence to Medical Regimens: Eyal Shemesh * SECTION VIII: PRINCIPLES OF CLINICAL INVESTIGATION * Outcomes Research on Diagnostic and Therapeutic Procedures: Jenifer R. Lightdale, Maireade McSweeney * Methodology: Statistical Analysis, Test Interpretation, Basic Principles of Screening with Application for Clinical Study: Patricia L. Hibberd, Andrew Cooper * Ethics/Regulatory Issues: P. Pearl O'Rourke, Jennifer P. Stevens