Main description:

This is a comprehensive and authoritative presentation of total intravenous anesthesia (TIVA) and target controlled infusion (TCI). The editors' international reputation has enabled them to recruit leading experts from around the world to write single-author chapters in their area of expertise. Total Intravenous Anesthesia and Target Controlled Infusions is the first multi-disciplinary, globally authored volume on the topic.
Providing a single source of information on all aspects of TIVA and TCI, from pharmacologic modeling and the pharmacology of intravenous anesthetic drugs to practical considerations in the clinical setting and the requirements of special populations, Total Intravenous Anesthesia and Target Controlled Infusions examines the debate about the risks and advantages of TIVA, analyze outcome studies, and provides guidance on creating a curriculum to teach TIVA and TCI.

Contents:

CONTENTS

PART 1. INTRODUCTION/BACKGROUND

1. When and How Did It All Begin? A Brief History of Intravenous Anesthesia

John Sear

2. The Development and Regulation of Commercial Devices for Target - Controlled Drug Infusion

John B Glen

3. The Memory Labyrinth: systems, processes and boundaries

Robert A. Veselis

4. Consciousness and Anaesthesia

Ram Adapa

5. Mechanisms of Intravenous Anaesthetic Action

Hugh C. Hemmings Jr and Karl F. Herold

PART 2. PRINCIPLES OF PHARMACOLOGICAL MODELING

6. Basic Pharmacology: Kinetics and Dynamics for Dummies

Johan Raeder

7. Pharmacokinetic-Pharmacodynamic Modelling of Anesthetic Drugs

Johannes Hans Proost

8. Principles of Target Controlled Infusions

Steven L. Shafer

9. Performance of Target-Controlled Infusion Systems

Matthew TV Chan

10. How to Select a PK/PD Model

Kenichi Masui

PART 3. PHARMACOLOGY OF THE INTRAVENOUS ANESTHETIC AGENTS

11. Propofol PK-PD

Douglas J. Eleveld

12. Etomidate and Etomidate Analogues: Molecular Pharmacology and Behavioral Actions

Douglas E. Raines

13. Dexmedetomidine: The Science and Clinical Aspects in Adults and Children

Mohamed Mahmoud

14. Clinical Effects and Applications of Ketamine

Mark G. Roback

15. Neuromuscular Blocking Drugs: Pharmacology, Physiology and Clinical Aspects

Claude Meistelman

16. New and Upcoming Drugs: Intravenous Anesthetic Agents John William Sear

17. Drug Interactions in Anesthesia

Jaap Vuyk

PART 4. PRACTICAL CONDUCT OF SEDATION AND ANESTHESIA

18. Pumps Pitfalls and Practicalities

Frank Engbers

19. EEG Monitoring of Depth of Anesthesia

Michael Sury

20. Monitoring the analgesic component of anesthesia

Isabelle Constant<

21. Intravenous Drugs for Sedation: Target Controlled, Patient Controlled, and Patient Maintained Delivery

Keith J Anderson and Gavin NC Kenny

22. Pediatric TIVA/TCI: Case Presentations and Discussion

Vivian Man-ying Yuen

23. TCI/TIVA Adult Case Studies

Nicholas Sutcliffe

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PART 5. SPECIAL POPULATIONS AND PROCEDURES

24. Intravenous Anesthesia in Obese Patients

Pablo Sepulveda and Ignacio Cortinez

25. Pharmacokinetics and Dynamics on the Pediatric Population

Brian J. Anderson

26. Clinical Pharmacology of Intravenous Sedation in Children

Oliver Bagshaw

27. Sedation of the Critically Ill Child

Arno Brouwers, Sanne Vaassen, Gijs D Vos, Jan NM Schieveld, and Piet L Leroy

28. TCI & TIVA for Neurosurgery: Considerations and Techniques

Massimo Lamperti and Fazil Ashiq

29. TCI in Special Patients Groups: The Elderly and Obese

Frederique S Servin

30. TIVA for Cardiac Surgery

Stefan Schraag

31. TIVA/TCI in Veterinary Practice

Thierry Beths

PART 6. OUTCOME, EDUCATION, SAFETY, AND THE FUTURE

32. Advantages, Disadvantages, and Risks of TIVA/TCI

Ken B Johnson

33. Economics of TIVA

Jane Montgomery and Mary Stocker

34. Teaching TCI with Human Patient Simulators

Wolfgang Heinrichs

35. Closed-Loop or Automated Titration of Intravenous Anesthesia: Background, Science and Clinical Impact

Ngai Liu

36. Health Care Technology, the Human-Machine Interface, and Patient Safety During Intravenous Anesthesia

Craig S. Webster

37. Can IV Sedatives Affect Outcome?

Christopher G. Hughes, Christina J. Hayhurst, and Pratik P. Pandharipande

38. The Benefit and Future of Pharmacogenetics

Janko Samardzic, Dubravka Svob Strac, and John N. van den Anker

39. Lessons from drug interaction displays

Ross Kennedy

40. The Role of Intravenous Agents in Delirium

Claudia Spies, Susanne Koch, Alissa Wolf, Rudolf Moergeli, and Bjoern Weiss

41. Perioperative Cardioprotective Strategies in Noncardiac Surgery

Stefan De Hert

42. Opioid Induced Hyperalgesia after Surgery: Clinical Relevance

Dr. Philippe Richebe

43. Memory, Awareness and Intravenous Anaesthetics

Michael Wang

44. Awareness and Dreaming During TIVA

Kate Leslie

45. Apoptosis and Neurocognitive Effects of Intravenous Anesthetics

Sulipicio Soriano and Laszlo Vutskits

Epilogues