Main description:

The volume describes the three-dimensional structural features of the molecules underlying the physiologic functions of biologic membranes. While this book has a rather clear focus on the membrane, as a major component of any cell, it will also cover the other crucially important functions within cells, further enhancing and deepening the understanding of biologic function. This knowledge is believed to be vital in the development of new pharmaceutical modalities, given that almost 50% of drug targets are thought to be membrane proteins.
This book is designed to be a reference text for a broad range of readers, from researchers in a variety of scientific and related medical fields, to graduate students working in these specialties. ​
 

Feature:

Provides up-to-date, detailed physiologic views of biologic membranes based on newly analyzed structures of membrane proteins
Focuses on the three-dimensional structures of membrane proteins, which will facilitate a deeper and clearer understanding of biologic function​

Contents:

1)      Construction of cells and importance of membrane proteins
2)      Lipid bilayer and lipid molecules
3)      Channels
a) ion channels
a-1) K+ channels
a-2) Na+ channels
a-3) Ca2+ channels
a-4) Voltage-sensitive channels
a-5) Ligand gated channels
a-6) Mechanosensitive channels
a-7) Other ion channels
b) Water channels
b-1) Aquaporin-0
b-2) Aquaporin-1
b-3) Aquaporin-2
b-4) Aquaporin-3
b-5) Aquaporin-4
b-6) Aquaporin-5
b-7) Aquaporin-6
b-8) Aquaporin-7
b-9) Aquaporin-8
b-10) Aquaporin-9
b-11) Aquaporin-10
b-12) Aquaporin-11and Aquaporin-12
b-13) Other water channels
c) Gap junction channels
d) Porins
e) Other channels
 
4)      Receptors
a) G protein-coupled receptors
a-1) Rhodopsin
a-2) GPCRs of non-peptidic ligand; b1 aderenergic receptor, b2 adrenergic receptor, A2 adrenergic receptor, Muscarinic Acetylcholine receptors・・・・
a-3) GPCRs of peptidic ligand; Chemokine receptors, Endothelin receptors・・・・
a-4) Sygnal transduction by GPCRs
b) Ionotropic receptors
b-1) AMPA receptors
b-2) NMDA receptors
b-3) Acetylcholine receptors
c) IP3 receptors
d) P2X family proteins
e) Photo receptors and Photosynthesis
f)  Other receptors
 
5)      Transporters and pumps
a) P-type ATPases
b) V-type ATPases
c) F-type ATPases
d) ABC transporters
e) Ion transporters
f) Syn-porters and Anti-porters
g) Proton pumps
h) Nuclear pore complexes
i) Translocators
j) Other transporters and pumps
 
6)      Motors
a) Flagella
b) Cilia
c) Other motors
 
7)      Enzymes
a) Enzymes for lipid modification
a-1) Prostaglandins
a-2) Microsomal glutathione synthetase (S-transferases)
a-3) Leukotriene synthase
b) Enzyme-coupled cell signaling
b-1) Tyrosine Kinases
b-2) Proteolysis of membrane proteins
c) Other enzymes
 
8)      Adhesive molecules
a) Cadherins
b) Integrins
c) Neuroligin-Neurexin
d) Claudin
e) Nectine
f) Other adhesive molecules
g) Fusion proteins
 
9)       Membrane dynamics
a) Cell division
b) Growth cone
c) Caveolins
d) Synapses
e) Blebs
f) Cell migration
g) Endocytosis and Exocytosis
h) Cell death
i) Immune system
j) Cancer cells
k) Cell differentiation
l) Characteristics of stem cells
 
10)   Structural physiology of biologic membranes
 
11)   Structural views of living organisms