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Main description:
Cells change their shape and by alternating their internalcytoskeleton. The dynamics of the cytoskeletal structure underlinethese changes, thus the signals that drive the changes must beinterpreted by cellular machinery in order to carry out therequired remodelling. Until recently, it has been very difficult toobtained detailed mechanistic information about these importantsignalling processes.
Understanding the processes that regulate cell morphology iscritical to understanding complex biological questions such as cellmigration during embryonic development, axonal guidance, or thebasis for metastasis of cancer cells.
This book contains contributions from experts in cell biology,genetics, neurobiology, immunology and structural biology, all ofwhom study processes of cell shape change and motility. Itaddresses key questions in this field, including the following. (1)What are the organising principles behind cell shape change? (2)Are there ′master switches′ present in every cell type? (3) How areextracellular signals interpreted by the cell in order to activateintracellular mechanisms? (4) What is the influence of theextracellular matrix on cell movement and internal signallingpathways? (5) How do pathogens subvert cellular systems in order tostimulate or block their uptake? There are also discussions of thepotential applications of the data to clinical problems,particularly the problems of cell motility in cancer.
This book should be of interest to molecular and cellbiologists, geneticists, neuroscientists, immunologists,oncologists and structural biologists.
Back cover:
Cells change their shape and by alternating their internalcytoskeleton. The dynamics of the cytoskeletal structure underlinethese changes, thus the signals that drive the changes must beinterpreted by cellular machinery in order to carry out therequired remodelling. Until recently, it has been very difficult toobtained detailed mechanistic information about these importantsignalling processes.
Understanding the processes that regulate cell morphology iscritical to understanding complex biological questions such as cellmigration during embryonic development, axonal guidance, or thebasis for metastasis of cancer cells.
This book contains contributions from experts in cell biology,genetics, neurobiology, immunology and structural biology, all ofwhom study processes of cell shape change and motility. Itaddresses key questions in this field, including the following. (1)What are the organising principles behind cell shape change? (2)Are there ′master switches′ present in every cell type? (3) How areextracellular signals interpreted by the cell in order to activateintracellular mechanisms? (4) What is the influence of theextracellular matrix on cell movement and internal signallingpathways? (5) How do pathogens subvert cellular systems in order tostimulate or block their uptake? There are also discussions of thepotential applications of the data to clinical problems,particularly the problems of cell motility in cancer.
This book should be of interest to molecular and cellbiologists, geneticists, neuroscientists, immunologists,oncologists and structural biologists.
Contents:
Novartis Foundation symposium on Signalling networks in cellshape and motility held in collaboration with the Institute of Celland Molecular Biology, Singapore, in Singapore on August 30th–1stSeptember 2004.
Editors:Gregory Bock (Organizer) and Jamie Goode.
This symposium is based on a proposal made by UttamSurana.
Gary Borisy Chair s introduction.
Tadaomi Takenawa – From N–WASP to WAVE: key molecules forregulation of cortical actin organization.
Discussion.
Margaret A. Titus – A conserved role for myosin VII inadhesion.
Discussion.
General discussion I.
David G. Drubin, Marko Kaksonen, Christopher Toret and Yidi Sun– Cytoskeletal networks and pathways involved in endocytosis.
Discussion.
Michele Knaus, Philippe Wiget,Yukiko Shimada and Matthias Peter– Control of cell polarity in response to intra– and extracellularsignals in budding yeast.
Discussion.
Fred Chang, Becket Feierbach and Sophie Martin – Regulation ofactin assembly by microtubules in fission yeast cell polarity.
Discussion.
Atsuo T. Sasaki and Richard A. Firtel – Finding the way:directional sensing and cell polarization through Rassignaling.
Discussion.
Takashi Watanabe, JuNoritake and Kozo Kaibuchi – Roles ofIQGAP1 in cell polarization and migration.
Discussion.
Gregg G. Gundersen,Ying Wen, Christina H. Eng, Jan Schmoranzer,Noemi Cabrera–Poch, EdwardJ. S.Morris,Michael Chen and Edgar R.Gomes – Regulation of microtubules by Rho GTPases in migratingcells.
Discussion.
Eyal D. Schejter – Actin organization in the early Drosophilaembryo.
Discussion.
Yasuyuki Fujita and Vania Braga – Epithelial cell shape and Rhosmall GTPases.
Discussion.
W. James Nelson, Frauke Drees and Soichiro – Yamada Interactionof cadherin with the actin cytoskeleton.
Discussion.
Martin J.Humphries, Zohreh Mostafavi–Pour, Mark R.Morgan,Nicholas O. Deakin, Anthea J. Messent and Mark D. Bass Integrin–syndecan co–operation governs the assembly of signallingcomplexes during cell spreading.
Discussion.
Keith Mostov, Paul Brakeman, Anirban Datta, Ama Gassama, LeonidKatz, Minji Kim, Pascale Leroy, Max Levin, Kathleen Liu, FernandoMartin, Lucy E. O Brien, Marcel Verges,Tao Su, Kitty Tang,Naoki Tanimizu,Toshiyuki Yamaji and Wei Yu – Formation ofmulticellular epithelial structures.
Discussion.
Kathryn M. Eisenmann, Jun Peng, Bradley J.Wallar and Arthur S.Alberts – Rho GTPase: formin pairs in cytoskeletal remodeling.
Discussion.
Final discussion.
Index of contributors.
Subject index.
PRODUCT DETAILS
Publisher: John Wiley & Sons Ltd (Wiley–Blackwell)
Publication date: October, 2008
Pages: 250
Dimensions: 167.00 x 234.00 x 17.00
Weight: 544g
Availability: Not available (reason unspecified)
Subcategories: Diseases and Disorders
From the same series
CUSTOMER REVIEWS
"Vital for all oncology researchers and endocrinologists, inaddition to cell biologists and instructors within these fields."( Electric Review, September/October 2006)
" contains contributions from a wide range ofexperts .the discussions are very stimulating and provideinsights " (Doody′s Health Services)