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Schizophrenia
Modern Concepts and Research Findings
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Main description:

Schizophrenia is a mental disorder that causes great suffering for patients and their families. The aetiology of schizophrenia is not known. It has been suggested that particular environmental factors and susceptibility genes in interaction make individuals more prone to develop the disorder. The pathophysiology of schizophrenia is subject to extensive research where genetics, environmental risk factors, neuropsychology, brain imaging, brain morphology and neurochemistry are some areas of rapid growth.After an introductory chapter on clinical features, this book focuses on these research areas, and gives a picture of important research findings and concepts. It also gives insights into clinical neuropsychological assessment, early detection and intervention, and pharmacological treatment. Historical backgrounds, important discoveries and concepts are presented as well as new technologies. The different chapters are written by highly recognised Scandinavian scientists. The book is primarily intended for healthcare professionals, students and researchers, but will also be informative for readers with a more general interest in schizophrenia in the light of new research.


Contents:

Clinical features of schizophrenia; Psychopathology of schizophrenia; DSM-IV criteria; Phenotypic subgroups of schizophrenia; Course of disease; Premorbid features of schizophrenia; Additional clinical features of schizophrenia; Concluding remarks; References; The genetic disposition; Genes and environment; The molecular biology of the human brain; Genetic approaches to schizophrenia; Linkage analysis; Association studies; COMT, schizophrenia and cognition; Candidate genes in schizophrenia; The dysbindin gene; The G72 and D-amino acid oxidase genes; The neuregulin-1 gene; Other approaches to understanding the pathophysiology using genetic tools; Will there be a breakthrough; Conclusion; Complications during the pre- and perinatal period; Exposure to prenatal infection; Season of birth; Urban living; Migration; Cannabis use; Epidemiological terms; Neuropsychology; Neuropsychology and neurocognition; Neurodevelopment; Vulnerability; Neuropsychological dysfunction and symptoms of schizophrenia; Clinical neuropsychological assessment; The consequences of impaired psychological functions in schizophrenia; Remediation of psychological functions; Functional imaging; Conceptual and methodological background; Psychomotor disturbances; Visual processing; Auditory perception; Selective attention; Working memory; Learning and retrieval of memories; Executive functions; Formal thought disorder; Imaging antipsychotic drug effects; Abnormalities of brain morphology: Evidence from MRI studies; Magnetic resonance imaging; MR image analysis; Brain morphology; Global and regional brain abnormalities; Changes over time; Gender differences; Can genetic variation explain differences in brain morphology; Relation between clinical and cognitive manifestations and brain morphology; Brain morphology of childhood and late life onset schizophrenia; Dopamine hypotheses; Dopaminergic pathways in the human brain; Dopamine receptors; What is the role of glutamate in schizophrenia; Glutamate receptors; Glutamate hypofunction hypothesis; Importance of serotonin; Substances of abuse neurochemical links to schizophrenia; Phencyclidine and amphetamine; Cannabis; Estrogens; Other proteins, peptides and amino acids connected to schizophrenia; Myelin; Nitric oxide; The premorbid period; The prodromal period; The early phases of psychosis; First episode treatment; Pharmacological treatment; Chlorpromazine the first antipsychotic drug; Clozapine; Mechanism of action of antipsychotic drugs; Receptor selectivity of antipsychotic drugs; PET studies on antipsychotic drugs; Second generation of antipsychotic drugs; Third generation of antipsychotic drugs; Antipsychotic drug effects on schizophrenia and bipolar affective disorder;


PRODUCT DETAILS

ISBN-13: 9789144029801
Publisher: Studentlitteratur AB
Publication date: June, 2008
Pages: 194
Dimensions: 225.00 x 155.00 x 11.00
Weight: 288g
Availability: Not available (reason unspecified)
Subcategories: Psychiatry

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