Main description:

This book provides a comprehensive, state-of-the art summary of platelet rich plasmas (PRPs) in the field of regenerative medicine. The book begins with an overview of the basic science behind PRP, describing the role of platelets and growth factors followed by the most important biological effects expected from the use of PRPs.

Platelet Rich Plasma in Orthopaedics, Sports Medicine and Maxillofacial Surgery includes numerous contributions detailing the current use of PRPs in clinical practice. From the origins in oral and maxillofacial surgery, to the latest advances in orthopaedics and sports medicine including the use of Platelet Rich Growth Factors (PRGF) in muscle, bone, tendon, ligament and nerve injuries, this book provides a wide scope of the topic. The volume concludes with chapters from experts in biology, orthopaedics, oral and maxillofacial surgery, where the convergence of expertise is leading to unprecedented insights into how to minutely control the in vivo fate and function of PRGF. This book will provide a useful resource for physicians and researchers interested in learning more about this rapidly growing area of biomedical treatment.

Contents:

Part 1. Basic science.- Platelets: at the interface between inflammation and repair process.- Characterization of plasma rich in growth factor: content and formulation.- Effects of PRGF on cells and tissues of musculoskeletal system: from muscle to articular cartilage.- Regeneration: connecting the dots among hemostasis and clotting, immune system, and fibrogenesis.- PRGF molecular intervention to enhance muscle perfusion and tissue remodeling.- Part 2. Oral and Maxillofacial surgery.- The use of plasma rich in growth factor in the treatment of post-extraction defects.- Efficacy and safety of PRGF versus platelet rich fibrin in post-extraction defects.- An autologous treatment to a challenging pathology medication-related osteonecrosis of the jaw. Part 3. Orthopaedics & Sports Medicine.- A biological approach to apply plasma rich in growth factors on joint tissues.- Scientific evidence of the effects of PRGF on musculoskeletal tissues in animal model.- A new approach to treat joint and cartilage injuries: intraosseous infiltrations of PRGF.- Knee Osteoarthritis: one versus two cycles of PRGF infiltrations treatment.- Application of PRGF on Sports-related injuries.- Why to use Plasma rich in growth factors on the repair of damaged tendons.- Infiltrations of PRGF to treat ligament injuries.- Treatment of injured peripheral nerves with PRGF: from bench to patient.- Treatment of tendinopathies with Plasma rich in growth factors.- Intradiscal and intra-articular facet infiltrations with plasma rich in growth factors to treat chronic low back pain.