Main description:

A successful seientific career requires constant effort on the part of the seientist. If such a career is to be achieved by seientists in developing countries where the faeilities are not easily available, even more dedication is required. Dr. K. M. Sivanandaiah, having completed a successful career in the field of peptide chemistry, is such a seientist. Being weIl aware of the limited research facilities available in India, we are extraordinarily appreciative of Professor Sivanandaiah's dedication to the advancement of science. As a Professor of Chemistry and, until his retirement in 1992, the Head of the Department of Studies in Chemistry at Bangalore University, India, he not only devoted much of his time to his students, teaching basic organic chemistry, but was also able to contribute to the field of peptide chemistry. After completing 25 years of service at Central College, Bangalore, where he was admired as an outstanding teacher, Professor Sivanandaiah is still active in research. He is now Professor Emeritus and continues to contribute to the field of peptides. As former students of Professor Sivanandaiah, we felt that publishing a book containing articles related to the design, synthesis, conformation, and biological activity of peptides and written by eminent scientists in the field of peptide research would be a fitting tribute to his role in the field of bioorganic chemistry.

Contents:

1 K. M. Sivanandaiah: Twenty-Five Years of Peptide Research in Central College, Bangalore University, Bangalore, India.- I Peptide Synthesis and Methodology.- 2 Catalytic Transfer Hydrogenation and Hydrogenolysis by Formic Acid and Its Salts.- 3 Syntheses of Natriuretic Peptides Using a New S-Protecting Group, S-Trimethylacetamidomethyl (Tacm) Group.- 4 Solid-Phase Synthesis of Cyclic Peptides.- 5 Enzymatic Semisynthesis of Growth Hormone-Releasing Factor and Potent Analogs.- 6 Recent Developments in the Synthesis of Glycopeptides.- II Peptide Design and Applications.- 7 Synthesis, Characterizations, and Medical Applications of Bioelastic Materials.- 8 Synthetic Peptides in the Study of Viral Fusion, Inflammation, and Atherosclerosis.- 9 "De Novo" Engineering of Peptide Immunogenic and Antigenic Determinants as Potential Vaccines.- 10 Complementary Peptides: Applications of the Molecular Recognition Theory to Peptide and Protein Purification and Design.- 11 Conformational Studies on Model Peptides and Peptidomimetics.- III Studies of Peptide Hormones.- 12 The Design and Synthesis of Long-Acting Oxytocin Antagonists Substituted in Positions 2, 7, and 8.- 13 Calcitonin: A Minireview.- 14 Importance of Ca2+-Hormone Interaction in Conformation-Activity Correlations.- IV Other Biologically Active Peptides.- 15 The Binding of Peptides and Proteins to Membranes Containing Anionic Lipid.- 16 Synthetic Peptides Mimic the Active Sites of Fibronectin Receptors from Gram-Positive Bacteria.- 17 Analyses of Various Folding Patterns of the HIV-1 Loop.- 18 Regulation of Human Immunodeficiency Virus Gene Expression by the Tat and Rev Proteins.