Hematology is often considered a challenging subject by students and junior medical staff alike. Using key scientific and clinical principles, this succinct guide provides a summary of modern day-to-day clinical practice in paediatric hematology. Focusing on the facts that underpin patient management, each chapter offers an initial summary of a particular paediatric hematologic condition. Several key clinical scenarios set out how common difficulties should be managed, from the neonate with line thrombosis, to the newly presenting patient with leukaemia, and the child who has suffered a stroke. Covering all hematology topics on the syllabus of the American Board of Paediatrics subspecialty examinations, this authoritative guide is ideal for both postgraduates and junior doctors, whose understanding of hematological conditions will increase greatly upon reading. This comprehensive and practical book specifically aims to equip clinicians to diagnose and manage children with hematological illness, and to support them and their families.
1. Normal hemopoiesis and the physiology of blood; 2. The coagulation system; 3. Common laboratory tests used in hematology and how to interpret them; 4. Reference ranges in children; Clinical scenario 1. The child with newly presenting acute leukemia; 5. Neonatal anemia; 6. Neonatal abnormal myelopoiesis and the hematology of Down syndrome; 7. Neonatal thrombocytopenia; 8. Neonatal bleeding disorders; Clinical scenario 2. Hyperleucocytosis; 9. Neonatal thrombotic disorders; 10. Inherited bone marrow failure syndromes; 11. Acquired bone marrow failure syndromes: aplastic anemia; 12. Sideroblastic anemia; Clinical scenario 3. Management of the child with a mediastinal mass; 13. Iron deficiency; 14. Disorders of vitamin B12 and folate; 15. Hemolytic anemia; 16. Infections in hematology patients and the hematological features of infectious disease; Clinical scenario 4. The approach to the neutropenic child with fever; 17. Sickle cell disease; 18. Thalassemia; 19. Neutropenia; 20. Neutrophil function disorders; Clinical scenario 5. The approach to the child with pancytopenia; 21. Inherited thrombocytopenia; 22. Acquired thrombocytopenia and immune thrombocytopenia purpura (ITP); 23. Immune deficiency; 24. Hemophagocytic Lymphohistiocytosis (HLH) and other non-malignant histiocytic disorders; Clinical scenario 6. Does this child have lymphoma?; 25. Osteopetrosis; 26. Hemophilia; 27. Congential and acquired von Willebrand disease; 28. Rare inherited bleeding disorders; Clinical scenario 7. Diamond-Blackfan anemia, transient erythroblastopenia or other cause of red cell aplasia in children; 29. Acquired bleeding disorders; 30. Venous thrombosis in children; 31. Arterial thrombosis in children; 32. Stroke in children; Clinical scenario 8. Approach to evaluation for a bleeding disorder in a child with suspected non-accidental injury (NAI); 33. Anticoagulation in children; 34. Blood transfusion indications and safe use in children; 35. Adverse reactions to blood products and special transfusion circumstances; 36. Acute lymphoblastic leukemia; Clinical scenario 9. The neonate with catheter related thrombosis; 37. Acute myeloid leukemia; 38. Juvenile myelomonocytic leukemia (JMML) and myelodysplastic syndromes (MDS); 39. Principles of blood and marrow transplantation; Clinical scenario 10. Neonatal renal vein thrombosis.