Main description:

This book discusses the importance of oxidative stress, related biomarkers, and its diagnostic methods including bio-analytical and advanced detection systems.

Oxidative stress is associated with diminished capacity of a biological system to overcome the overproduction of reactive oxygen species. Since oxidative stress has been suggested as a causative factor in many diseases, its prevention is vital, and there is an urgent need for oxidative stress monitoring using in vitro and in vivo models. Interdisciplinary approaches have lead to the development of various oxidative stress monitoring models for real-world clinical and biomedical applications. The development of such methods requires a broad understanding of biology, chemistry, molecular biology, immunology and microbiology. As such, the book is a valuable resource for students, researchers and clinicians interested in the fundamental as well as applied aspects of oxidative stress associated diseases.

Contents:

Introduction

1.1 Free radicals and reactive oxygen species (ROS)/reactive nitrogen species (RNS)

1.2

1.3 Redox potential and protection against oxidative stress

1.4 Oxidative stress and diseases

Importance of oxidative stress monitoring

Oxidative stress monitoring using in vitro models

3.1 Oxidative stress monitoring using different cell culture

3.2 Oxidative stress monitoring using blood samples

3.3 Oxidative stress monitoring using other biological samples

Oxidative stress monitoring using in vivo models

4.1 Oxidative stress monitoring using transgenic mouse model

4.2 Oxidative stress monitoring using Zebra fish

4.3 Oxidative stress monitoring using other biological in vivo models

Detection of oxidative stress biomarkers using biosensors

5.1 Concept and principle of biosensors

5.2 Gold nanoparticle based colorimetric methods for biomarkers of oxidative stress

5.3 Biosensor for in vitro detection of cancer and bacterial cells

5.4 Detection of neurotransmitters, DNA, Proteins etc.

5.5 Biosensors for online monitoring

5.6 Microsensor arrays

6. Future prospects and challenges