Main description:

This compendium provides a wide view covering everything from molecular mechanisms and risk factors for neurological disorders to the effects of bariatric surgery on brain function and functional neuroimaging applied to obesity research. The impact of obesity on brain function and the development of neurodegenerative and neuroinflammatory disorders has been understudied, despite the recent proliferation of obesity research. Among the topics covered are adipose biology, the adipose tissue - gut - brain axis, brain energy metabolism, dementia, cerebrovascular disease, and multiple sclerosis.

Contents:

I. Adipose Tissue Biology and Crosstalks

I.1 Function and Dysfunction of Adipose Tissue (Paulo Matafome, Raquel Seica)

I.2 Neuroendocrinology of Adipose Tissue-Brain Axis (Paulo Matafome, Raquel Seica)

I.3 Neuroendocrinology of Gut-Brain Axis (Paulo Matafome, Raquel Seica)

II. Obesity as a Risk Factor for Neurological Disease

II.1 Classification and Epidemiology of Obesity (Bruno Almeida, Barbara Aguiar)

II.2 Diabetes and Brain Energy Metabolism (Paula Moreira)

II.3 The Impact of Adipocyte Dysfunction on Hypothalamus (Claudia Cavadas)

II.4 Dementia: Influence of Adipokines on Brain Development and Aging (Liliana Letra, Isabel Santana)

II.5 Cerebrovascular Disease: Consequences of Obesity-Induced Endothelial Dysfunction (Cristina Sena, Liliana Letra)

II.6 Multiple Sclerosis: Implications of Obesity in Neuroinflammation (Sonia Batista)

III. Brain Function after Bariatric Surgery: Modulation of Energy Homeostasis and Cognitive Performance (Hans Eickhoff)

IV. Animal Models and Obesity Research (Raquel Seica, Paulo Matafome)