Main description:

Neurochemical Aspects of Alzheimer's Disease provides a comprehensive overview of molecular aspects of risk factors, pathogenesis, biomarkers, and therapeutic strategies. The book focuses on molecular mechanisms and signal transduction processes associated with the pathogenesis, biomarkers, and therapeutic strategies of AD. The comprehensive and cutting edge information in this monograph may not only help in early detection of AD, but also promote discovery of new drugs to treat this chronic disease. Chapters discuss involvement of neural membrane phospholipids, sphingolipids, and cholesterol-derived lipid mediators, abnormal APP processing, and nucleic acid damage, risk factors, biomarker, and therapeutic strategies of Alzheimer's disease. This book is written for neurologists, neuroscientists, neurochemists, neuropharmacologists, and clinicianswho are interested in molecular mechanisms associated with the pathogenesis of age-related neurological disorders.

Contents:

1. Neurochemical Aspects of ss-Amyloid Cascade Hypothesis for Alzheimer's Disease: A Critical Evaluation 2. Risk Factors for Alzheimer's Disease 3. Contribution of Neural Membrane Phospholipids (Sphingolipids) and Cholesterol in the Pathogenesis of Alzheimer's Disease 4. Contribution of Nucleic Acids in the Pathogenesis of Alzheimer's Disease 5. Type 2 Diabetes and Metabolic Syndrome as Risk Factors for Alzheimer's Disease 6. Contribution of Neuroinflammation in the Pathogenesis of Alzheimer's Disease 7. Biomarkers for Alzheimer's Disease 8. Potential Treatments for Alzheimer's Disease 9. Immunotherapy for the Treatment of Alzheimer's Disease 10. Perspective, Summary, and Directions for Future Research on Alzheimer's Disease