Main description:

There is a growing body of knowledge that simplified diets (high fat, high sugar, low fiber) negatively affect aspects of gut barrier function including increased susceptibility to transient and persistent colonization of extra-intestinal pathogenic bacteria, changes to gut barrier morphology, innate and acquired immunity and pro-inflammatory state of the gut. The book discusses natural products such as polyphenols, anthocyanins, flavonols, proanthocyanidins, and hydrolyzable tannins as a whole food approach or as supplements to simplified diets, and the role they play in modulating these aspects of gut barrier function.

Contents:

Effect of oligomeric polyphenols on functional morphology of gut barrier function(goblet cells & panneth cells). Polyphenol modulation of innate immune system (Muc-2, IL-4, IL-13, sPLA2). Effects of polyphenols on adaptive immune system (sIgA & PIgR). Enterohepatic circulation and metabolism of monomeric polyphenols. Effects of simplified diets (high fat/hi sugar) on aspects of gut barrier function. Role of natural products in modulation of dysbiosis (prebiotic and probiotic). Tannin modulation of macrophage activation.