Main description:

As the molecular basis of human disease becomes better characterized, and the implications for understanding the molecular basis of disease becomes realized through improved diagnostics and treatment, Molecular Pathology, Second Edition stands out as the most comprehensive textbook where molecular mechanisms represent the focus. It is uniquely concerned with the molecular basis of major human diseases and disease processes, presented in the context of traditional pathology, with implications for translational molecular medicine.

The Second Edition of Molecular Pathology has been thoroughly updated to reflect seven years of exponential changes in the fields of genetics, molecular, and cell biology which molecular pathology translates in the practice of molecular medicine. The textbook is intended to serve as a multi-use textbook that would be appropriate as a classroom teaching tool for biomedical graduate students, medical students, allied health students, and others (such as advanced undergraduates). Further, this textbook will be valuable for pathology residents and other postdoctoral fellows that desire to advance their understanding of molecular mechanisms of disease beyond what they learned in medical/graduate school. In addition, this textbook is useful as a reference book for practicing basic scientists and physician scientists that perform disease-related basic science and translational research, who require a ready information resource on the molecular basis of various human diseases and disease states.

Contents:

1. Molecular Mechanisms of Cell Death 2. Acute and Chronic Inflammation Induces Disease Pathogenesis 3. Infection and Host Response 4. Neoplasia 5. Basic Concepts in Human Molecular Genetics 6. The Human Genome: Implications for the Understanding of Human Disease 7. The Human Transcriptome: Implications for the Understanding of Human Disease 8. The Human Epigenome: Implications for the Understanding of Human Disease 9. Clinical Proteomics and Molecular Pathology 10. Integrative Systems Biology: Implications for the Understanding of Human Disease 11. Pathology: The Clinical Description of Human Disease 12. Understanding Molecular Pathogenesis: Implications for Improved Treatment of Human Disease 13. Integration of Molecular and Cellular Pathogenesis: A Bioinformatics Approach 14. Molecular Basis of Cardiovascular Disease 15. Molecular Basis of Hemostatic and Thrombotic Diseases 16. Molecular Basis of Lymphoid and Myeloid Diseases 17. Molecular Basis of Diseases of Immunity 18. Molecular Basis of Pulmonary Disease 19. Molecular Basis of Diseases of the Gastrointestinal Tract 20. Molecular basis of Liver Disease 21. Molecular basis of diseases of the exocrine pancreas 22. Molecular Basis of Diseases of the Endocrine System 23. Molecular Basis of Gynecologic Diseases 24. Molecular Basis of Kidney Disease 25. Molecular Pathogenesis of Prostate Cancer 26. Molecular Biology of Breast Cancer 27. Molecular Basis of Skin Disease 28. Molecular Basis of Bone diseases 29. Molecular Basis of Diseases of the Nervous System 30. Molecular Diagnosis of Human Disease 31. Molecular Assessment of Human Disease in the Clinical Laboratory 32. Pharmacogenomics and Personalzed Medicine in the Treatment of Human Disease