Main description:

This text covers the basic principles of mitochondrial dynamics in cardiovascular medicine, with particular emphasis on their functional roles in physiology and disease. The book will include articles pertaining to mitochondrial fitness on a global basis, providing therefore an update on the progress made in several aspects in the field. Thus, it will assist scientists and clinicians alike in furthering basic and translational research. Organized in sections focusing on: basic science, mitochondrial dysfunction in cardiac disorders, in vascular disorders, in metabolic disorders, in kidney disease, therapeutic challenges and options, this essential volume fills imperative gaps in understanding and potentially treating several cardiovascular disorders.

Contents:

Cardiac metabolic remodelling: hypoxia vs. failure .- Nitric Oxide and Mitochondrial Biogenesis .- Nitrite-nitric oxide signaling and cardioprotection .- Mitochondrial mutations in cardiac disorders .- Mitochondria and cardiac hypertrophy .- Functional implications of the clustering of cardiac mitochondria .- Mechanistic role of thioredoxin 2 in heart failure .- Mitochondrial bioenergetics during ischemia/reperfusion .- Peripheral blood mitochondrial DNA and myocardial function .- Mitochondria and angiogenesis .- Mitochondrial oxidative stress and atherosclerosis .- Apolipoproteins and mitochondrial function .- Mitochondria and glucose homeostasis .- Insulin resistance and mitochondrial dysfunction .- Mitochondria and cardiorenal syndrome .- Mitochondrial damage in kidney disease .- Prohibitin-2 and kidney function .- Mitochondrial heteroplasmy .- Mitochondrial transplantation.