Main description:

This book provides a comprehensive overview of how use of micro- and nanotechnology (MNT) has allowed major new advance in vaccine development research, and the challenges that immunologists face in making further progress.

MNT allows the creation of particles that exploit the inherent ability of the human immune system to recognize small particles such as viruses and toxins. In combination with minimal protective epitope design, this permits the creation of immunogenic particles that stimulate a response against the targeted pathogen. The finely tuned response of the human immune system to small particles makes it unsurprising that many of the lead adjuvants and vaccine delivery systems currently under investigation are based on nanoparticles.

Contents:

Overview of immune system.
Innate immunity and special role of antigen presenting cells.
Immunity and size.
Introduction to the vaccines.
Current challenges in vaccine development.
Growing role of nanotechnology
Nanotechnology in medical research
Nanoparticle based peptide vaccines
Liposome as nano- and microvaccines
Lipid in peptide vaccine (excluding liposomes)
Nanoadjuvants for peptide based vaccines
Nanopatches for vaccine delivery
Oral vaccine delivery
Nano- and microtechnology in skin delivery of vaccines
Nasal vaccine delivery
Nanoparticles for cancer targeting vaccines by
polymer based nanovaccines
Lipidic microparticles for vaccine delivery
Polymeric microparticles for vaccine delivery