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MORE ABOUT THIS BOOK
Main description:
This book intends to bring together, a panel of renowned experts in the field of vascular biology and diabetology, to integrate the current understanding of the pathogenesis and pathophysiology of vascular diseases in diabetes mellitus. This attempt is significant given the increasing interest in this area as the prevalence of vascular diseases continues to escalate globally. Patients with diabetes are at a higher risk of structural and functional changes in all vessel walls of the human body. Vascular complications of diabetes are leading causes for both morbidity and mortality.
In recent years, several articles have focused on advancing our knowledge on the profound effect of hyperglycemia and insulin resistance on building up vascular wall inflammation leading to endothelial dysfunction in patients with diabetes mellitus Other reports have elaborated on the various disorders, hyperglycemia can lead to, their therapies, adverse effects and complications. There are also studies that highlight the role of factors that induce vascular wall alterations in hyperglycemia.
In this book, we attempt to discuss vascular disease progression in diabetes with a unique approach. We attempt to provide a complete perspective of the pathophysiology of vascular complications and then dissect each of the factors that play a key role in accelerating vascular wall alterations in diabetes. Each of these factors has been adversely implicated in the initiation and progression of disease to a large extent. In this collection for the first time all these factors would be described under a common canopy. Further, the text would emphasize on pathogenesis of micro vascular complications of diabetes, such as retinopathy, neuropathy and nephropathy. Pharmacological therapies for treating vascular dysfunction in diabetes mellitus would also be reviewed. This compendium hopefully would be an invaluable replacement to scores of literature on diabetic vascular disease and would be of great interest to clinicians, academicians, medical students and researchers.
The book will be divided into seven sections, each emphasizing a common incentive to development of vascular disease in diabetes. Section I deals with pathophysiology of diabetic vascular disease, beginning with an update on the global burden of diabetes mellitus and its vascular complications. The pathophysiology and pathogenesis of diabetes associated macrovasculopathy, how hyperglycemia functions as an atherogenic factor, effects of hyperglycemia on smooth muscle accumulation in vascular lesions and genetic susceptibility for increased risk of vascular disease in diabetes will be discussed in the following chapters of this section.
The next section (Section II) surveys the process of endothelial dysfunction under hyperglycaemia and hyperinsulinemia and their effects on angiogenesis, vascular remodeling and wound healing. A chapter is also dedicated to the endothelial progenitor cell population and its dysfunction during development of vascular complications in diabetes.
Section III will highlight the molecular mechanisms underlying endothelial dysfunction, various pathways such as nitric oxide synthase pathway, oxidative stress pathway, renin - angiotensin system and increased vascular superoxide production in the initiation and progression of vascular disease in diabetes. This section also covers role of endothelin, monocyte derived cytokines, peroxynitrate and adipokines in macrovascular complications of diabetes.
Metabolic factors such as advanced glycation end products, atherogenic dyslipoproteinaemia, and homocysteine will be reviewed in Section IV, whereas an overview of the hemostatic factors such as platelet dysfunction, hyperglycaemia induced thrombin formation and aberrant clot lysis will be dwelled upon in Section V.Section VI includes chapters on microvascular complications of diabetes which encompasses long term complications of diabetes affecting small blood vessels of the eye, kidneys and nervous system. The pathogenesis and mechanisms of these complications would be detailed here.
The final section (Section VII) of the book will consider mechanism of action of drugs for treating endothelial dysfunction in diabetes mellitus which would elaborate on lipid regulating therapies such as statins, as well as other therapies such as ACE inhibitors, Angiotensin II receptors, insulin, metformin and their effects on enhancing vascular function in diabetes.
Contents:
SECTION I: Pathophysiology
Chapter 1. The global burden of diabetes and its vascular complications
Dr V. Mohan
Madras Diabetes Research Foundation
No 4, Conran Smith Road,
Gopalapuram,
Chennai - 600 086
India
Email: drmohans@diabetes.ind.in
Chapter 2. Diabetes-associated macrovasculopathy: pathophysiology and pathogenesis
School of Medical Sciences
University Sains Malaysia
Kelantan
Malaysia
Email: seempi2005@yahoo.co.uk
Chapter 3. Diabetes as an atherogenic factor
Dr Sampath Parthasarathy
Burnett School of Biomedical Sciences
UCF College of Medicine
6900 Lake Nona Blvd.<
Orlando
Fl 32827
USA
Email: spartha@ucf.edu
Chapter 4. Effects of diabetes on smooth muscle accumulation in lesions of atherosclerosis
Dr L.A. Suzuki
Department of Pathology
University of Washington
Seattle 98195-7470
USA
Email:
Chapter 5. Genetic basis for increased risk for vascular disease in diabetes
Dr Adebowale Adeyemo
Center for Research on Genomics and Global Health
National Human Genome Research Institute
National Institutes of Health Bethesda
MD
USA
Email: adeyemoa@mail.nih.gov
SECTION II: Endothelial dysfunction and diabetes
Chapter 6. The role of hyperglycaemia and hyperinsulinaemia in causing vascular dysfunction in diabetes
Dr Cristina M. Sena
Institute of Physiology
Faculty of Medicine
University of Coimbra
3000-548 Coimbra
Portugal
Email: csena@ci.uc.pt
Chapter 7. Endothelial dysfunction in hyperglycemia and hyperinsulinemia
Professor Madhulika Dixit
Department of Biotechnology
Indian Institute of Technology Madras
Chennai - 600 036
India
Email: mdixit@iitm*ac*in
Chapter 8. Endothelial dysfunction and diabetes: Effects on angiogenesis, vascular remodeling, and wound healing
Dr Gopi Krishna Kolluru
Department of Pathology
LSU Health Sciences Center-Shreveport
1501 Kings Highway
LA 71130
USA
Email:
Chapter 9. Endothelial progenitor cell dysfunction in the pathogenesis of vascular complications of diabetes
Dr Adriana Georgescu
Institute of Cellular Biology and Pathology 'NicolaeSimionescu' of Romanian Academy
8,B.P.Hasdeu Street
PO Box 35-14
Bucharest
Romania
Email: adriana.georgescu@ icbp.ro<
SECTION III: Molecular mechanisms
Chapter 10. Mechanisms underlying endothelial dysfunction and impaired vascular reactivity in diabetes mellitus
Professor Piruthivi Sukumar
Department of Biosciences and Bioengineering
Indian Institute of Technology
Guwahati
Assam - 781039
India
Email: p.sukumar@iitg.ernet.in
Chapter 11. Nitric oxide synthase pathway in diabetes mellitus
Dr Tomoko Asagami
Department of Cardiovascular Medicine
Stanford University School of Medicine
291 Campus Drive
Li Ka Shing Building
Stanford
CA 94305-5101
USA
Email:
Chapter 12. The role of endothelin in diabetic vascular complications
Dr T. Matsumoto
Department of Physiology and Morphology
Institute of Medicinal Chemistry
Hoshi University<
Shinagawa-ku
Tokyo 142-8501
Japan
Email: t-matsu@hoshi.ac.jp
Chapter 13. Oxidative stress and diabetic vascular complications
Dr Atsunori Kashiwagi
Shiga University of Medical Science
Otsu
Shiga
Japan
Email: kasiwagi@belle.shiga-med.ac.jp
Chapter 14. Mechanisms of increased vascular superoxide production in human diabetes mellitus
Professor Tomasz Guzik
Institute of Cardiovascular and Medical Sciences
University of Glasgow
Glasgow
G12 8QQ
UK
Email: Tomasz.Guzik@glasgow.ac.uk
Chapter 15. Peroxynitrite and vascular endothelial dysfunction in diabetes mellitus
Dr Azza B. El-Remessy
College of Pharmacy
Medical College of Georgia
The University of Georgia
Augusta
GA 30912
Chapter 16. Monocyte derived cytokines and pathogenesis of vascular lesions in diabetes
Dr Surya Ramachandran
Rajiv Gandhi Center for Biotechnology
Thycaud Post
Poojappura
Thiruvananthapuram - 695 014
Kerala
India
Email: suryaramachandran@rgcb.res.in
Chapter 17. The renin-angiotensin system and the long-term complications of diabetes
Professor Jennifer Wilkinson Berka
Department of Immunology,
Monash Medical School Building
Level 5, The Alfred Centre
Monash University
Melbourne
VIC 3004
Australia
Email: jennifer.wilkinson-berka@monash.edu
Chapter 18. Adipokines and vascular disease in diabetes
Professor Camille de Moura Balarini
Bioitechnology Center
Federal University of Paraiba<
Joao Pessoa
Brazil
Email:
SECTION IV: Metabolic factors
Chapter 19. Advanced glycation end products and diabetic complications
Professor Mark E. Cooper
Albert Einstein Juvenile Diabetes Research Foundation Centre for Diabetes Complications Diabetes and Metabolism Division
Baker Medical Research Institute
P.O. Box 6492
St. Kilda Road Central
Melbourne
Victoria 8008
Australia
Email: mark.cooper@baker.edu.au
Chapter 20. Atherogenicdyslipoproteinemia in type 2 diabetes mellitus
Professor Rafael Carmena
Department of Medicine and Endocrinology
University of Valencia
Valencia E-46010
Spain
Email: Rafael.Carmena@uv.es
Chapter 21. Homocysteine and diabetic vasculopathy
Professor Martin Buysschaert<
Service d'EndocrinologieetNutri-tion
CliniquesUniversitaires St. Luc
Avenue Hippocrate 54
UCL 54.74
B-1200 Bruxelles
Belgium
Email : martin.buysschaert@uclouvain.be
SECTION V: Hemostatic factors
Chapter 22. Diabetes as a prothrombotic condition
Professor Peter Grant
Academic Unit of Molecular Vascular Medicine
Leeds Institute for Genetics, Health and Therapeutics
Faculty of Medicine and Health
University of Leeds
Clarendon Way
Leeds
LS1 3EX
UK
Email: P.J.Grant@leeds.ac.uk
Chapter 23. Platelet dysfunction in type 2 diabetes
Professor Dominick J. Angiolillo
Division of Cardiology
University of Florida-Jacksonville
5th Floor, Ambulatory Care Center
655 West 8th Street, C35
Jacksonville
FL 32209
USA
Email: dominick.angiolillo@jax.ufl.edu
Chapter 24. Hyperglycemia-induced thrombin formation in diabetes
Professor Anetta Undas
Institute of Cardiology
Jagiellonian University Medical College
80 Pradnicka Street
31-202 Krakow
Poland
Email: mmundas@cyf-kr.edu.pl
Chapter 25. Mechanisms for aberrant clot lysis in diabetic subjects
Dr E.J. Dunn
Academic Unit of Molecular Vascular Medicine
Leeds Institute for Genetics, Health and Therapeutics
Faculty of Medicine and Health
University of Leeds
Clarendon Way
Leeds
LS1 3EX
UK
Email:
SECTION VI: Diabetic microvasculopathy
Chapter 26. Diabetes and retinal vascular disorders
Dr Jennifer Wilkinson-Berka
Department of Immunology
Monash University
AMREP
Alfred Centre
Melbourne
Victoria 3004
Australia
Email: jennifer.wilkinson-berka@monash.edu
Chapter 27. Pericytes and the pathogenesis of diabetic retinopathy
Professor Hans Peter Hammes
5th Medical Department
University Hospital Mannheim
University of Heidelberg
Theodor-Kutzer-Ufer 1-3
68167 Mannheim
Germany
Email: peter.hammes@med5.ma.uni-heidelberg.de
Chapter 28. Mechanisms of microvascular damage in human diabetic neuropathy
Dr Peter J. Dyck
Department of Neurology
Mayo Clinic
Rochester
MN 55905
USA
Email: Peter@mayo.edu
Chapter 29. Pathogenesis of diabetic nephropathy
Dr Stephanie Toth-Manikowski
Division of Nephrology
Johns Hopkins University
1830 E. Monument Street
Suite 416
Baltimore
MD 21287
USA
Email: stephanie.toth-manikowski@bmc.org
SECTION VII: Pharmacological therapies
Chapter 30. Mechanisms of action of drugs for treating endothelial dysfunction in diabetes mellitus
Dr Sanjay K Banerjee
Translational Health Science & Technology Institute
NCR Biotech Science Cluster,
3rd Milestone, Faridabad - Gurgaon Expressway,
PO box #04,
Faridabad - 121001
India
Email: skbanerjee@thsti.res.in
PRODUCT DETAILS
Publisher: Springer (Springer International Publishing AG)
Publication date: August, 2017
Pages: None
Weight: 652g
Availability: Available
Subcategories: Cardiovascular Medicine, Endocrinology