Main description:

Divided into two volumes the work offers a so far unmatched broad and at the same time deep knowledge on molecular and cellular mechanisms of carcinogenesis and offers comprehensive insight into clinical, therapeutic and technological aspects. This 1st Volume presents tumor entities of the ocular system, the thyroid organ, the oesophagus, gliomas, non-glial brain tumors, head and neck as well as lung cancer. In addition it also discusses in-depth potential novel molecular players and the role of stem cells as well as the endocannabinoid system in carcinogenesis, it furthermore explains tumor metabolism components and signaling pathways. Each of the chapters discusses potential therapeutic strategies and novel drug targets.

The book addresses basic scientists and medical researchers interested in translational cancer research.

Contents:

Preface.- Modern technologies.- MACC1, a novel player in solid cancer carcinogenesis.- The endocannabinoid system in carcinogenesis.- Stem cells in carcinogenesis.- Insulin pathways and carcinogenesis.- Role of Triglyceride Lipases in Tumor Metabolism.- mTOR signalling in carcinogenesis.- Nuclear Factor Kappa B.- Gliomas.- Non-glial brain tumors.- Ocular neoplasms.- Thyroid carcinogenesis.- Head and Neck including Oral cavity, Larynx, Pharynx.- Oesophagus.- Lung Carcinogenesis.- Progression of lung cancer: role of hypoxia and the metabolic tumor microenvironment.