BOOKS BY CATEGORY
Your Account
Life Histories of Genetic Disease
Patterns and Prevention in Postwar Medical Genetics
Price
Quantity
€42.70
(To see other currencies, click on price)
Hardback
Add to basket  

MORE ABOUT THIS BOOK

Main description:

Medical geneticists began mapping the chromosomal infrastructure piece by piece in the 1970s by focusing on what was known about individual genetic disorders. Five decades later, their infrastructure had become an edifice for prevention, allowing today's expecting parents to choose to test prenatally for hundreds of disease-specific mutations using powerful genetic testing platforms. In Life Histories of Genetic Disease, Andrew J. Hogan explores how various diseases were "made genetic" after 1960, with the long-term aim of treating and curing them using gene therapy. In the process, he explains, these disorders were located in the human genome and became targets for prenatal prevention, while the ongoing promise of gene therapy remained on the distant horizon. In narrating the history of research that contributed to diagnostic genetic medicine, Hogan describes the expanding scope of prenatal diagnosis and prevention. He draws on case studies of Prader-Willi, fragile X, DiGeorge, and velo-cardio-facial syndromes to illustrate that almost all testing in medical genetics is inseparable from the larger-and increasingly "big data"-oriented-aims of biomedical research.
Hogan also reveals how contemporary genetic testing infrastructure reflects an intense collaboration among cytogeneticists, molecular biologists, and doctors specializing in human malformation. Hogan critiques the modern ideology of genetic prevention, which suggests that all pregnancies are at risk for genetic disease and should be subject to extensive genomic screening. He examines the dilemmas and ethics of the use of prenatal diagnostic information in an era when medical geneticists and biotechnology companies have begun offering whole genome prenatal screening-essentially searching for any disease-causing mutation. Hogan's focus and analysis is animated by ongoing scientific and scholarly debates about the extent to which the preventive focus in contemporary medical genetics resembles the aims of earlier eugenicists. Written for historians, sociologists, and anthropologists of science and medicine, as well as bioethics scholars, physicians, geneticists, and families affected by genetic conditions, Life Histories of Genetic Disease is a profound exploration of the scientific culture surrounding malformation and mutation.


Contents:

Preface Acknowledgments Introduction: Pursuing a Better Birth Chapter 1 Genetics Detectives Chapter 2 Chromosomal Cartography Chapter 3 The Genome's Morbid Anatomy Chapter 4 Seeing with Molecules Chapter 5 Institutionalized Disorders Chapter 6 Getting the Whole Picture Epilogue: The Genomic Gaze Notes Index


PRODUCT DETAILS

ISBN-13: 9781421420745
Publisher: Johns Hopkins University Press
Publication date: December, 2016
Pages: 256
Dimensions: 152.00 x 229.00 x 24.00
Weight: 522g
Availability: Available
Subcategories: Diseases and Disorders, Ethics, General Issues, Genetics

CUSTOMER REVIEWS

Average Rating