Main description:

This text encompass an up-to-date, comprehensive review of the state-of-the-art for gland preserving therapies. Fully updated and revised, this text evaluates the scientific evidence for the evolving trend to treat intermediate risk, clinically localized prostate cancer in a focally ablative manner with novel gland-preserving, focal therapy methods. Various ablative devices such as high intensity focused ultrasound, irreversible electroporation, photodynamic therapy, cryotherapy and laser ablation, among others, is discussed in regard to their strengths and limitations as a therapeutic modality. Emphasis is placed on patient selection and outcomes utilizing both advanced imaging techniques and pathologic evaluation.

Current and new approaches to image cancer foci within the prostate (multiparametric ultrasonography, multiparametric magnetic resonance image, etc) are presented along with various biopsy techniques, including robotics to map prostate cancer. Patient selection based on imaging and genomic classification, adjuvants to enhance therapy, treatment strategy, outcomes and patient centered concerns is discussed, providing an acceptable balance between cancer control and improved quality of life for patients.

Written by experts in the field and lavishly illustrated with detailed line-art and photographs, Imaging and Focal Therapy of Early Prostate Cancer, Second Edition is designed as a comprehensive resource for urologists, radiation oncologists, medical oncologists, radiologists, uropathologists, molecular biologists, biomedical engineers, other clinicians -- residents, fellows, nurses and allied professionals -- and researchers with an interest in the diagnosis and novel treatment of prostate cancer. It will provide insight into the latest research and clinical applications of image-guided diagnosis and minimally invasive focal, gland-preserving treatment for prostate cancer.

Contents:

Table of Contents

Imaging and Focal Therapy of Early Prostate Cancer, 2E

Editor: Thomas J. Polascik

Foreword

Jean J. M. C. H. de la Rosette

Preface

Acknowledgments

Contributors

Section 1: Why Focal Therapy?

Chapter 1. Evolution in the Concept of Focal Therapy: the Story of Breast Cancer and Prostate Cancer Isabel Garcia-Fleury, Chi-hang Yee, Marco Antonio Lopez-Tovar, Adriana Pesci-Feltri, Arjun Sivaraman, and Rafael Sanchez-Salas

Chapter 2 Targeted Therapy for Localized Kidney Cancer

Zhamshid Okhunov, Roshan M. Patel, and Jaime Landman

Chapter 3. Focal Therapy for Prostate Cancer: A Guide for Patients

Kae Jack Tay and Thomas J. Polascik

Section 2: Global Perspective of Active Surveillance and Focal Therapy

Chapter 4. Low-Risk Prostate Cancer in North America: Rationale, Uptake, and Limitations of Active Surveillance and Opportunities for Focal Therapy

Raj Satkunasivam and Laurence Klotz

Chapter 5. Focal Therapy and Active Surveillance in Europe

Jan Philipp Radtke, Angelo Territo, Markus R. Hohenfellner, and Alberto Breda

Chapter 6. Focal Therapy and Active Surveillance of Prostate Cancer in East and Southeast Asia Masaki Kimura, Kae Jack Tay, Satoru Muto, and Shigeo Horie

Section 3: Scientific Foundation for the Focal Therapy Concept

Chapter 7. Pathologic Rationale for Focal Therapy of Prostate Cancer: Elucidating Tumor Characteristics and Biology

Vladimir Mouraviev, Arnauld Villers , Thomas M. Wheeler, Rodolfo Montironi, Pierre Nevoux, Ariel Schulman, and Thomas J. Polascik

Chapter 8. Identifying and Characterizing the Index Lesion

Lina M. Carmona Echeverria, Hayley Whitaker, and Hashim U. Ahmed

Chapter 9. Utilizing Biopsy-Based Genomic Assays to Risk-Stratify Patients

Robert Qi, Stephen J. Freedland, and Judd W. Moul

Chapter 10. Patient Selection for Focal Therapy of Prostate Cancer

Arjun Sivaraman and Rafael Sanchez-Salas

Chapter 11. Prostate Focal Therapy: Definitions and Common Terminology

John F. Ward

Section 4: Multiparametric MRI and ARFI Imaging of the Prostate

Chapter 12. Reading and Reporting Standards: The Prostate Imaging Reporting And Data System - What Is It and What Can It Do?

Wulphert Venderink and Jurgen J. Futterer

Chapter 13. Role of Magnetic Resonance Imaging in Prostate Cancer Assessment

Sonia Gaur, Sherif Mehralivand, Baris Turkbey, and Peter L. Choyke

Chapter 14. Optimizing Multiparametric Magnetic Resonance Imaging for a Focal Therapy Practice: Quality Improvement

Jamie N. Holtz and Rajan T. Gupta

Chapter 15. Acoustic Radiation Force Impulse Imaging for Targeting: Correlation with Histology

Mark L. Palmeri and Kathryn R. Nightingale

Section 5: Prostate Biopsy Techniques

Chapter 16. In-Bore Magnetic Resonance Imaging-Targeted Biopsy

Igor Trilisky, Aytekin Oto, and Scott Eggener

Chapter 17. Multiparametric MRI-TRUS Fusion Biopsy, Outcomes, and Commercial Systems

Akhil Muthigi, Ardeshir R. Rastinehad, Arvin K. George, Masakatsu Oishi, Osamu Ukimura, and Peter A. Pinto

Chapter 18. Detecting, Localizing, and Treating the Multiparametric Magnetic Resonance Imaging Invisible Lesion: Utilizing Three-Dimensional Transperineal Mapping

Nelson N. Stone and E. David Crawford

Chapter 19. Multiparametric Transrectal Ultrasound Biopsy

Arnoud W. Postema, Jochen Walz, and Hessel Wijkstra

Chapter 20. Robotic Magnetic Resonance Imaging Targeting for Biopsy and Therapy Wesley W. Ludwig, Mohamad E. Allaf, and Dan Stoianovici

Section 6: Technologies for Focal Therapy: Transperineal Approach

Chapter 21. In-Bore Transperineal Magnetic Resonance Imaging-Guided Laser Ablation

Nathan Perlis, John Trachtenberg, and Sangeet Ghai

Chapter 22. Focal Cryoablation

Kae Jack Tay, Efrat Tsivian, and Thomas J. Polascik

Chapter 23. Photodynamic Therapy for Early Prostate Cancer

Caroline M. Moore and Mark Emberton

Section 7: Technologies for Focal Therapy: Transrectal Approach

Chapter 24 High-Intensity Focused Ultrasound

Paolo Capogrosso and Eric Barret

Chapter 25. Transrectal Laser Focal Therapy of Prostate Cancer

John F. Feller, Bernadette M. Greenwood, and R. Jason Stafford

Section 8: New Approaches and Applications of Focal Therapy

Chapter 26. Focal Therapy for Prostate Cancer: a Molecular Biology Approach with TRAIL

Vikram Narayan, Badrinath R. Konety, and Thomas S. Griffith

Chapter 27. Focal Brachytherapy and Intensity Modulated Radiation Therapy

R. Alex Hsi

Chapter 28. Focal Therapy for Anterior Cancers (Originated from Transition Zone)

Arnauld Villers and Kae Jack Tae

Section 9: Manipulating the Microenvironment for Optimization

Chapter 29. The Story of Adjuvants to Boost the Performance of Cryoablation Kimberly L. Santucci, John M. Baust, Kristi K. Snyder, Anthony Robilotto, Robert G. VanBuskirk, and John G. Baust

Chapter 30. 5-Alpha-Reductase Inhibition as a Secondary Preventive Strategy Nathan Perlis and Antonio Finelli

Section 10: Determining Outcomes of Focal Therapy

Chapter 31. Measuring Patient-Based Outcomes: Setting Realistic Expectations When Balancing Functional Outcomes with Cancer Control

Behfar Ehdaie and Arjun Sivaraman

Chapter 32. Pathologic Assessment and Implications Following Focal Therapy of Prostate Cancer

Rafael E. Jimenez, Andrew Evans, James Kench, Rodolfo Montironi, and Mahul B. Amin

Chapter 33. Post-Treatment Surveillance Using Multiparametric Magnetic Resonance Imaging

Alex Kirkham

Chapter 34. Determining Focal Therapy Failure and Salvage Options Theo M. de Reijke, Arnoud W. Postema, and J. Stephen Jones

Chapter 35. Positioning Focal Therapy from Consensus to Guidelines

Matthijs J. V. Scheltema, Anouk E. Hentschel, and Jean J. M. C. H. de la Rosette