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Histamine Receptors as Drug Targets
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Main description:

This book illustrates the current state-of-the-art in histamine research, with a focus on the appropriate methodologies to investigate the pharmacological properties and the therapeutic exploitation of HRs and their ligands. In addition, the range of techniques described provides an introduction to complementary cross-methodological disciplines beyond these fields. This multi-disciplinary approach is required to define the 'decision gates' that determine the development of more effective and safer therapeutic options for many forms of highly prevalent and debilitating diseases, such as asthma, dementias, dermatitis, and arthritis. Written for the Methods in Pharmacology and Toxicology series, chapters concentrate on practical, hands-on protocols from experts in the techniques.
Authoritative and thorough, Histamine Receptors as Drug Targets seeks to aid pharmacologists, biochemists, drug discovery researchers, molecular biologists, chemists, toxicologists, lab scientists, medical doctors, principle investigators, research scientists, lab directors and technicians, as well as graduate students around the world in pursuing the study of this vital scientific area.


Contents:

1. Methodologies to Identify and Analyze Genetic Polymorphisms for Human Histamine Receptors

Stephany Micallef and Astrid Sasse

2. Development, Characterization, and Validation of Anti-Human H3 Receptor Isoform-Specific Antibodies

Fiona C. Shenton, Natasha Lethbridge, and Paul L. Chazot

3. Approaches to Recombinant Histamine H3/H4 Receptor Expression in Mammalian Cells

Tadeusz Karcz, Urszula Cichon, and Katarzyna Kiec-Kononowicz

4. Histamine H2 Receptor Biased Signaling Methods

Natalia Fernandez, Carina Shayo, Carlos Davio, and Federico Monczor

5. Ligand-Binding Kinetics on Histamine Receptors

Reggie Bosma, Tamara A.M. Mocking, Rob Leurs, and Henry F. Vischer

6. Methods to Study the Molecular Pharmacology of the Histamine H4 Receptor

Eleonore W.E. Verweij, Rob Leurs, and Henry F. Vischer

7. Chemiluminescence: A Sensitive Method for Detecting the Effects of Histamine Receptor Agonists/Antagonists on Neutrophil Oxidative Burst

Ondrej Vasicek, Tomas Perecko, Viera Jancinova, Silvia Pazourekova, Radomir Nosal, and Milan Ciz

8. Techniques Used in Pharmacological Evaluation of Histamine H4 Receptor Function on Native Human Eosinophils

Marek Grosicki and Katarzyna Kiec-Kononowicz

9. Assessment of the Efficacy of Histamine Receptor Antagonists in Murine Models of Atopic Dermatitis

Kristine Rossbach, Hanna Koechling, Tomoki Fukuyama, Jenny Wilzopolski, Manfred Kietzmann, and Wolfgang Baumer

10. Methodological Approaches to Study Histamine Pharmacology in the Kidney: From Cell Culture and Cell Imaging to Functional Assays and Electron Microscopy

Alessandro Pini, Eleonora Veglia, Cristina Grange, and Arianna Carolina Rosa

11. Histamine and the Kidney: In Vivo Animal Models

Alessandro Pini, Eleonora Veglia, and Arianna Carolina Rosa

12. Methodological Approaches to Investigate the Effects of Histamine Receptor Targeting Compounds in Preclinical Models of Breast Cancer

Diego J. Martinel Lamas, Melisa B. Nicoud, Helena Sterle, Graciela P. Cricco, Gabriela A. Martin, Graciela A. Cremaschi, Hubert G. Schwelberger, Elena S. Rivera, and Vanina A Medina

13. Evaluation of Histidine Decarboxylase (HDC) Activity and Human Histamine Receptor 3 (H3R) and HDC mRNA Levels

Carlos Acosta-Andrade, Jose L Urdiales, Ignacio Fajardo, and Francisca Sanchez-Jimenez

14. Cerebrospinal Fluid Markers in Neuroinflammation: The Paradigm of Optic Neuritis

Dimitrios P. Besinis and Maria C. Anagnostouli

15. In Vivo Diagnostic Procedures for IgE-Mediated Allergic Disorders

Christopher Koulias, Xenophon Aggelides, Caterina Chliva, and Michael Makris

16. Dermatological Indications of Antihistamines

Chrysovalantis Korfitis, Efstathios Rallis, and Dimitrios Rigopoulos

17. Histamine Quantification in Human Blood Samples

Ekaterini Tiligada, Maria Kakolyri, and Madeleine Ennis


PRODUCT DETAILS

ISBN-13: 9781493968411
Publisher: Springer (Humana Press Inc.)
Publication date: March, 2017
Pages: None
Weight: 652g
Availability: Available
Subcategories: Pharmacology

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