This book provides a comprehensive, state-of-the art review of HBV infection and liver disease. It discusses new data on basic and translational medicine, including the viral life cycle, the immunopathogenesis of virus-induced chronic hepatitis, viral and host genetic factors affecting disease progression, and the mechanism of virus-induced hepatocarcinogenesis, as well as their potential applications in daily clinical practice. The clinical aspects of chronic HBV infection are examined in chapters on the global epidemiology, efficacy of HBV vaccination, natural history, co-infections with HCV, HDV or HIV, and management of special populations including children, pregnant women and patients undergoing immunosuppressive therapy. Further, it describes the advances and perspectives in the development of novel antiviral treatments as possible cures for HBV infection. The book is a valuable resource for medical students, physicians, and researchers who are interested in management of patients with chronic HBV infection and investigation of HBV infection.
Life cycle and molecular virology.- Unmet needs in basic research: in vitro and in vivo models.- Immunopathogenesis.- Epidemiology and natural history.- Hepatitis B vaccination.- Viral factors and disease progression.- Host genetic factors and disease progression.- Molecular carcinogenesis of HCC.- Interferon therapy and long-term outcomes.- Nucleotide therapy and long-term outcomes.- Combination therapy.- Treatment of patients with HCV, HDV or HIV co-infection.- Management of children and pregnant women.- Management of patients with immunosuppressive therapy.- Towards an HBV cure: discovery of novel agents.- Others: occult HBV infection.